Molecular Biology group
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Latest research outputs
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RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes
Kiskinis, E., Hallberg, M., Christian, M., Olofsson, M., Dilworth, S., White, R. and Parker, M. 2007. RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes. The EMBO Journal. 26 (23), pp. 4831-4840. https://doi.org/10.1038/sj.emboj.7601908Article
Polyoma virus and simian virus 40 as cancer models: history and perspectives
Atkin, S., Griffin, B. and Dilworth, S. 2009. Polyoma virus and simian virus 40 as cancer models: history and perspectives. Seminars in Cancer Biology. 19 (4), pp. 211-217. https://doi.org/10.1016/j.semcancer.2009.03.001Article
Phosphorylation of translation factors in response to anoxia in turtles, Trachemys scripta elegans: role of the AMP-activated protein kinase and target of rapamycin signalling pathways
Rider, M., Hussain, N., Dilworth, S. and Storey, K. 2009. Phosphorylation of translation factors in response to anoxia in turtles, Trachemys scripta elegans: role of the AMP-activated protein kinase and target of rapamycin signalling pathways. Molecular and Cellular Biochemistry. 332 (1-2), pp. 207-213. https://doi.org/10.1007/s11010-009-0193-3Article
AMP-activated protein kinase and metabolic regulation in cold-hardy insects
Rider, M., Hussain, N., Dilworth, S., Storey, J. and Storey, K. 2011. AMP-activated protein kinase and metabolic regulation in cold-hardy insects. Journal of Insect Physiology. 57 (11), pp. 1453-1462. https://doi.org/10.1016/j.jinsphys.2011.07.006Article
Polyomavirus middle T-antigen is a transmembrane protein that binds signaling proteins in discrete subcellular membrane sites
Zhou, A., Ichaso, N., Adamarek, A., Zila, V., Forstova, J., Dibb, N. and Dilworth, S. 2011. Polyomavirus middle T-antigen is a transmembrane protein that binds signaling proteins in discrete subcellular membrane sites. Journal of Virology. 85 (7), pp. 3046-3054. https://doi.org/10.1128/JVI.02209-10Article
Dyskeratosis congenita and the DNA damage response
Kirwan, M., Beswick, R., Walne, A., Hossain, U., Casimir, C., Vulliamy, T. and Dokal, I. 2011. Dyskeratosis congenita and the DNA damage response. British Journal of Haematology. 153 (5), pp. 634-643. https://doi.org/10.1111/j.1365-2141.2011.08679.xArticle
Examination of hemiplasy, homoplasy and phylogenetic discordance in chromosomal evolution of the Bovidae
Robinson, T. and Ropiquet, A. 2011. Examination of hemiplasy, homoplasy and phylogenetic discordance in chromosomal evolution of the Bovidae. Systematic Biology. 60 (4), pp. 439-450. https://doi.org/10.1093/sysbio/syr045Article
Structure and expression of a newt cardio-skeletal myosin gene. Implications for the C value paradox
Casimir, C., Gates, P., Ross-Macdonald, P., Jackson, J., Patient, R. and Brockes, J. 1988. Structure and expression of a newt cardio-skeletal myosin gene. Implications for the C value paradox. Journal of Molecular Biology. 202 (2), pp. 287-296.Article
Evidence for dedifferentiation and metaplasia in amphibian limb regeneration from inheritance of DNA methylation.
Casimir, C., Gates, P., Patient, R. and Brockes, J. 1988. Evidence for dedifferentiation and metaplasia in amphibian limb regeneration from inheritance of DNA methylation. Development (Cambridge, England). 104 (4), pp. 657-68.Article
Purification of the 47 kDa phosphoprotein associated with the NADPH oxidase of human neutrophils
Teahan, C., Totty, N., Casimir, C. and Segal, A. 1990. Purification of the 47 kDa phosphoprotein associated with the NADPH oxidase of human neutrophils. The Biochemical Journal. 267 (2), pp. 485-489.Article
Characterization of the 47-kilodalton autosomal chronic granulomatous disease protein: tissue-specific expression and transcriptional control by retinoic acid
Rodaway, A., Teahan, C., Casimir, C., Segal, A. and Bentley, D. 1990. Characterization of the 47-kilodalton autosomal chronic granulomatous disease protein: tissue-specific expression and transcriptional control by retinoic acid. Molecular and cellular biology. 10 (10), pp. 5388-5396.Article
The alpha subunit of cytochrome b-245 mapped to chromosome 16
Bu-Ghanim, H., Casimir, C., Povey, S. and Segal, A. 1990. The alpha subunit of cytochrome b-245 mapped to chromosome 16. Genomics. 8 (3), pp. 568-70.Article
Autosomal recessive chronic granulomatous disease caused by deletion at a dinucleotide repeat
Casimir, C., Bu-Ghanim, H., Rodaway, A., Bentley, D., Rowe, P. and Segal, A. 1991. Autosomal recessive chronic granulomatous disease caused by deletion at a dinucleotide repeat. Proceedings of the National Academy of Sciences of the United States of America. 88 (7), pp. 2753-2757.Article
Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytes
Stewart, G., Hepworth-Jones, B., Keen, J., Dash, B., Argent, A. and Casimir, C. 1992. Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytes. Blood. 79 (6), pp. 1593-1601.Article
Identification of the defective NADPH-oxidase component in chronic granulomatous disease: a study of 57 European families
Casimir, C., Chetty, M., Bohler, M., Garcia, R., Fischer, A., Griscelli, C., Johnson, B. and Segal, A. 1992. Identification of the defective NADPH-oxidase component in chronic granulomatous disease: a study of 57 European families. European Journal of Clinical Investigation. 22 (6), pp. 403-406. https://doi.org/10.1111/j.1365-2362.1992.tb01481.xArticle
Restoration of superoxide generation to a chronic granulomatous disease-derived B-cell line by retrovirus mediated gene transfer
Thrasher, A., Chetty, M., Casimir, C. and Segal, A. 1992. Restoration of superoxide generation to a chronic granulomatous disease-derived B-cell line by retrovirus mediated gene transfer. Blood. 80 (5), pp. 1125-1129.Article
Chronic granulomatous disease: towards gene therapy.
Thrasher, A., Segal, A. and Casimir, C. 1993. Chronic granulomatous disease: towards gene therapy. Immunodeficiency. 4 (1-4), pp. 327-33.Article
Low NADPH oxidase activity in Epstein-Barr-virus-immortalized B-lymphocytes is due to a post-transcriptional block in expression of cytochrome b558
Chetty, M., Thrasher, A., Abo, A. and Casimir, C. 1995. Low NADPH oxidase activity in Epstein-Barr-virus-immortalized B-lymphocytes is due to a post-transcriptional block in expression of cytochrome b558. The Biochemical Journal. 306, pp. 141-145.Article
Gene transfer to primary chronic granulomatous disease monocytes
Thrasher, A., Casimir, C., Kinnon, C., Morgan, G., Segal, A. and Levinsky, R. 1995. Gene transfer to primary chronic granulomatous disease monocytes. Lancet. 346 (8967), pp. 92-93. https://doi.org/10.1016/S0140-6736(95)92116-8Article
Functional reconstitution of the NADPH-oxidase by adeno-associated virus gene transfer
Thrasher, A., De Alwis, M., Casimir, C., Kinnon, C., Page, K., Lebkowski, J., Segal, A. and Levinsky, R. 1995. Functional reconstitution of the NADPH-oxidase by adeno-associated virus gene transfer. Blood. 86 (2), pp. 761-5.Article
Generation of recombinant adeno-associated virus (rAAV) from an adenoviral vector and functional reconstitution of the NADPH-oxidase
Thrasher, A., De Alwis, M., Casimir, C., Kinnon, C., Page, K., Lebkowski, J., Segal, A. and Levinsky, R. 1995. Generation of recombinant adeno-associated virus (rAAV) from an adenoviral vector and functional reconstitution of the NADPH-oxidase. Gene therapy. 2 (7), pp. 481-485.Article
Molecular analysis in three cases of X91: variant chronic granulomatous disease
Bu-Ghanim, H., Segal, A., Keep, N. and Casimir, C. 1995. Molecular analysis in three cases of X91: variant chronic granulomatous disease. Blood. 86 (9), pp. 3575-3582.Article
Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14
Gillett, G., Fox, M., Rowe, P., Casimir, C. and Povey, S. 1996. Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14. Annals of Human Genetics. 60 (Pt 3), pp. 201-211.Article
Enhanced retroviral transduction of 5-fluorouracil-resistant human bone marrow (stem) cells using a genetically modified packaging cell line
Povey, J., Weeratunge, N., Marden, C., Sehgal, A., Thrasher, A. and Casimir, C. 1998. Enhanced retroviral transduction of 5-fluorouracil-resistant human bone marrow (stem) cells using a genetically modified packaging cell line. Blood. 92 (11), pp. 4080-4089.Article
Retroviral transduction of quiescent haematopoietic cells using a packaging cell line expressing the membrane-bound form of stem cell factor
Sehgal, A., Weeratunge, N. and Casimir, C. 1999. Retroviral transduction of quiescent haematopoietic cells using a packaging cell line expressing the membrane-bound form of stem cell factor. Gene therapy. 6 (6), pp. 1084-1091.Article
Haemophilias: advances towards genetic engineering replacement therapy.
Emilien, G., Maloteaux, J., Penasse, C., Goodeve, A. and Casimir, C. 2000. Haemophilias: advances towards genetic engineering replacement therapy. Clinical and laboratory haematology. 22 (6), pp. 313-23. https://doi.org/10.1046/j.1365-2257.2000.00332.xArticle
Differentiation-dependent up-regulation of p47(phox) gene transcription is associated with changes in PU.1 phosphorylation and increased binding affinity
Marden, C., Stefanidis, D., Cunninghame-Graham, D. and Casimir, C. 2003. Differentiation-dependent up-regulation of p47(phox) gene transcription is associated with changes in PU.1 phosphorylation and increased binding affinity. Biochemical and Biophysical Research Communications. 305 (1), pp. 193-202. https://doi.org/10.1016/S0006-291X(03)00727-7Article
A functional ISRE is required for myeloid transcription of the p47(phox) gene
Marden, C., Cunninghame-Graham, D., Thrasher, A. and Casimir, C. 2003. A functional ISRE is required for myeloid transcription of the p47(phox) gene. Biochimica et biophysica acta. 1630 (2-3), pp. 117-122. https://doi.org/10.1016/j.bbaexp.2003.09.005Article
Enhancer-deleted retroviral vectors restore high levels of superoxide generation in a mouse model of CGD.
Schwickerath, O., Brouns, G., Thrasher, A., Kinnon, C., Roes, J. and Casimir, C. 2004. Enhancer-deleted retroviral vectors restore high levels of superoxide generation in a mouse model of CGD. Journal of Gene Medicine. 6 (6), pp. 603-15.Article
Growth factor displayed on the surface of retroviral particles without manipulation of envelope proteins is biologically active and can enhance transduction.
Chandrashekran, A., Gordon, M., Darling, D., Farzaneh, F. and Casimir, C. 2004. Growth factor displayed on the surface of retroviral particles without manipulation of envelope proteins is biologically active and can enhance transduction. Journal of Gene Medicine. 6 (11), pp. 1189-96.Article
Targeted retroviral transduction of c-kit+ hematopoietic cells using novel ligand display technology
Chandrashekran, A., Gordon, M. and Casimir, C. 2004. Targeted retroviral transduction of c-kit+ hematopoietic cells using novel ligand display technology. Blood. 104 (9), pp. 2697-2703. https://doi.org/10.1182/blood-2003-10-3717Article
Circulating haematopoietic progenitors are differentially reduced amongst subtypes of dyskeratosis congenita
Kirwan, M., Vulliamy, T., Beswick, R., Walne, A., Casimir, C. and Dokal, I. 2008. Circulating haematopoietic progenitors are differentially reduced amongst subtypes of dyskeratosis congenita. British Journal of Haematology. 140 (6), pp. 719-22. https://doi.org/10.1111/j.1365-2141.2008.06991.xArticle
Exogenous TERC alone can enhance proliferative potential, telomerase activity and telomere length in lymphocytes from dyskeratosis congenita patients
Kirwan, M., Beswick, R., Vulliamy, T., Nathwani, A., Walne, A., Casimir, C. and Dokal, I. 2009. Exogenous TERC alone can enhance proliferative potential, telomerase activity and telomere length in lymphocytes from dyskeratosis congenita patients. British Journal of Haematology. 144 (5), pp. 771-81. https://doi.org/10.1111/j.1365-2141.2008.07516.xArticle
Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes
Boyhan, A., Casimir, C., French, J., Teahan, C. and Segal, A. 1992. Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes. The Journal of Biological Chemistry. 267 (5), pp. 2928-2933.Article
Post-transcriptional regulation of the chicken thymidine kinase gene
Groudine, M. and Casimir, C. 1984. Post-transcriptional regulation of the chicken thymidine kinase gene. Nucleic Acids Research. 12 (3), pp. 1427-46.Article
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