An exploratory study to identify risk factors for the development of capecitabine-induced palmar plantar erythrodysesthesia (PPE)

Article

Law, A., Dyson, S. and Anthony, D. 2015. An exploratory study to identify risk factors for the development of capecitabine-induced palmar plantar erythrodysesthesia (PPE). Journal of Advanced Nursing. 71 (8), pp. 1825-1832. https://doi.org/10.1111/jan.12639
TypeArticle
TitleAn exploratory study to identify risk factors for the development of capecitabine-induced palmar plantar erythrodysesthesia (PPE)
AuthorsLaw, A., Dyson, S. and Anthony, D.
Abstract

Aims: to identify pre-treatment risk factors for the development of Palmar Plantar Erythrodysesthesia in participants receiving capecitabine monotherapy.
Specifically the hypothesis that avoidance of activities that cause friction and pressure cause Palmar Plantar Erythrodysesthesia was tested.
Background. Previous literature showed contradictory evidence on the subject of predictors of chemotherapy-induced Palmar Plantar Erythrodysesthesia. There is a lack of empirical evidence to support the theory that Palmar Plantar Erythrodysesthesia is caused by damage to the microcapillaries due to everyday activities that cause friction or pressure to the hands or feet.
Design. Prospective epidemiological study of risk factors.
Methods. Prospective data collection. All patients prior to commencing capecitabine monotherapy between 11 June 2009–31 December 2010, were offered recruitment into the study and followed up for six cycles of treatment (n = 174). Data were collected during semi-structured interviews, from participants’ diaries, physical examination of the hands and feet and review of notes. Data relating to activities that cause friction, pressure or heat were collected. Data were analysed using bivariate (chi-square and independent groups Student’s t) tests where each independent variable was analysed against Palmar Plantar Erythrodysesthesia.
Results. The only variables that were associated with an increased risk of Palmar Plantar Erythrodysesthesia were a tendency to have warm hands and pre-existing inflammatory disease.
Conclusions. This study gives no support for the hypothesis that avoidance of activities that cause friction and pressure cause Palmar Plantar Erythrodysesthesia.

PublisherWiley
JournalJournal of Advanced Nursing
ISSN0309-2402
Publication dates
Print20 Feb 2015
Publication process dates
Deposited23 Apr 2015
Accepted15 Jan 2015
Output statusPublished
Accepted author manuscript
Copyright Statement

This is the peer reviewed version of the following article: [Law, Annie and Dyson, Sue E. and Anthony, Denis (2015) An exploratory study to identify risk factors for the development of capecitabine-induced palmar plantar erythrodysesthesia (PPE). Journal of Advanced Nursing], which has been published in final form at http://dx.doi.org/10.1111/jan.12639 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving, http://olabout.wiley.com/WileyCDA/Section/id-820227.html#terms .

Additional information

Article first published online: 20 FEB 2015

Digital Object Identifier (DOI)https://doi.org/10.1111/jan.12639
LanguageEnglish
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