Biomimetic strategies for fracture repair: engineering the cell microenvironment for directed tissue formation
Article
Vas, W., Shah, M., Al Hosni, R., Owen, H. and Roberts, S. 2017. Biomimetic strategies for fracture repair: engineering the cell microenvironment for directed tissue formation. Journal of Tissue Engineering. 8, pp. 1-14. https://doi.org/10.1177/2041731417704791
| Type | Article |
|---|---|
| Title | Biomimetic strategies for fracture repair: engineering the cell microenvironment for directed tissue formation |
| Authors | Vas, W., Shah, M., Al Hosni, R., Owen, H. and Roberts, S. |
| Abstract | Complications resulting from impaired fracture healing have major clinical implications on fracture management strategies. Novel concepts taken from developmental biology have driven research strategies towards the elaboration of regenerative approaches that can truly harness the complex cellular events involved in tissue formation and repair. Advances in polymer technology and a better understanding of naturally derived scaffolds have given rise to novel biomaterials with an increasing ability to recapitulate native tissue environments. This coupled with advances in the understanding of stem cell biology and technology has opened new avenues for regenerative strategies with true clinical translatability. These advances have provided the impetus to develop alternative approaches to enhance the fracture repair process. We provide an update on these advances, with a focus on the development of novel biomimetic approaches for bone regeneration and their translational potential. |
| Keywords | Fracture repair; biomimetic; endochondral ossification; biomaterials; stem cells |
| Publisher | Sage Journals |
| Journal | Journal of Tissue Engineering |
| ISSN | 2041-7314 |
| Publication dates | |
| Online | 24 Apr 2017 |
| 01 Jan 2017 | |
| Publication process dates | |
| Deposited | 04 May 2017 |
| Accepted | 21 Mar 2017 |
| Output status | Published |
| Publisher's version | License |
| Accepted author manuscript | |
| Copyright Statement | Vas, W. J., Shah, M., Al Hosni, R., Owen, H. C., & Roberts, S. J. (2017). Biomimetic strategies for fracture repair: Engineering the cell microenvironment for directed tissue formation. Journal of Tissue Engineering. Copyright © The Author(s) 2017 DOI: https://doi.org/10.1177/2041731417704791 |
| Digital Object Identifier (DOI) | https://doi.org/10.1177/2041731417704791 |
| Web of Science identifier | WOS:000400288900001 |
| Language | English |
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