Overcoming chemoresistance in osteosarcoma: the role of autophagy in cell death or survival following chemotherapy
Conference poster
Rosa, G., Burczynska, B., Stordal, B. and Roberts, H. 2018. Overcoming chemoresistance in osteosarcoma: the role of autophagy in cell death or survival following chemotherapy. 2018 NCRI Cancer Conference. Glasgow, Scotland 04 - 06 Nov 2018
Type | Conference poster |
---|---|
Title | Overcoming chemoresistance in osteosarcoma: the role of autophagy in cell death or survival following chemotherapy |
Authors | Rosa, G., Burczynska, B., Stordal, B. and Roberts, H. |
Abstract | Background: For the past 30 years, long-term survival rates in metastatic and recurrent osteosarcoma (OS) patients has remained unchanged. Drug resistance is thought to be the main cause and overcoming this phenomenon is a key step towards greater efficacy with OS therapy. Increasing evidence shows that autophagy, a ‘self-degradation’ pathway, can act as a protective mechanism to help cancer cells thrive under chemotherapeutic stress. The current study investigated the function of autophagy in two OS cell lines of varying metastatic capacity in response to two standard chemotherapy treatments, doxorubicin and cisplatin. |
Sustainable Development Goals | 3 Good health and well-being |
Research Group | Biomarkers for Cancer group |
Conference | 2018 NCRI Cancer Conference |
Publication dates | |
04 Nov 2018 | |
Publication process dates | |
Deposited | 07 Jul 2022 |
Accepted | 05 Aug 2018 |
Output status | Published |
Web address (URL) | https://abstracts.ncri.org.uk/abstract/overcoming-chemoresistance-in-osteosarcoma-the-role-of-autophagy-in-cell-death-or-survival-following-chemotherapy/ |
Language | English |
https://repository.mdx.ac.uk/item/89x79
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