Geographical and socioeconomic inequalities in female breast cancer incidence and mortality in Iran: A Bayesian spatial analysis of registry data

Article


Rahimzadeh, S., Burczynska, B., Ahmadvand, A., Sheidaei, A., Khademioureh, S., Pazhuheian, F., Saeedi Moghaddam, S., Bentham, J., Farzadfar, F. and Di Cesare, M. 2021. Geographical and socioeconomic inequalities in female breast cancer incidence and mortality in Iran: A Bayesian spatial analysis of registry data. PLoS ONE. 16 (3), pp. 1-19. https://doi.org/10.1371/journal.pone.0248723
TypeArticle
TitleGeographical and socioeconomic inequalities in female breast cancer incidence and mortality in Iran: A Bayesian spatial analysis of registry data
AuthorsRahimzadeh, S., Burczynska, B., Ahmadvand, A., Sheidaei, A., Khademioureh, S., Pazhuheian, F., Saeedi Moghaddam, S., Bentham, J., Farzadfar, F. and Di Cesare, M.
Abstract

Background
In Iran, trends in breast cancer incidence and mortality have generally been monitored at national level. The purpose of this study is to examine province-level disparities in age-standardised breast cancer incidence versus mortality from 2000 to 2010 and their association with socioeconomic status.
Methods
In this study, data from Iran’s national cancer and death registry systems, and covariates from census and household expenditure surveys were used. We estimated the age-standardised incidence and mortality rates in women aged more than 30 years for all 31 provinces in the consecutive time intervals 2000–2003, 2004–2007 and 2008–2010 using a Bayesian spatial model.
Results
Mean age-standardised breast cancer incidence across provinces increased over time from 15.0 per 100,000 people (95% credible interval 12.0,18.3) in 2000–2003 to 39.6 (34.5,45.1) in 2008–2010. The mean breast cancer mortality rate declined from 10.9 (8.3,13.8) to 9.9 (7.5,12.5) deaths per 100,000 people in the same period. When grouped by wealth index quintiles, provinces in the highest quintile had higher levels of incidence and mortality. In the wealthiest quintile, reductions in mortality over time were larger than those observed among provinces in the poorest quintile. Relative breast cancer mortality decreased by 16.7% in the highest quintile compared to 10.8% in the lowest quintile.
Conclusions
Breast cancer incidence has increased over time, with lower incidence in the poorest provinces likely driven by underdiagnoses or late-stage diagnosis. Although the reported mortality rate is still higher in wealthier provinces, the larger decline over time in these provinces indicates a possible future reversal, with the most deprived provinces having higher mortality rates. Ongoing analysis of incidence and mortality at sub-national level is crucial in addressing inequalities in healthcare systems and public health both in Iran and elsewhere.

LanguageEnglish
PublisherPublic Library of Science
JournalPLoS ONE
ISSN1932-6203
Publication dates
Print17 Mar 2021
Publication process dates
Deposited06 Apr 2021
Accepted03 Mar 2021
Output statusPublished
Publisher's version
License
Copyright Statement

Copyright: © 2021 Rahimzadeh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Digital Object Identifier (DOI)https://doi.org/10.1371/journal.pone.0248723
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