Repositioning of the global epicentre of non-optimal cholesterol

Article


NCD Risk Factor Collaboration (NCD-RisC), Taddei, C., Zhou, B., Bixby, H., Carrillo-Larco, R., Danaei, G., Jackson, R., Farzadfar, F., Sophiea, M., Di Cesare, M., Iurilli, M., Martinez, A., Asghari, G., Dhana, K., Gulayin, P., Kakarmath, S., Santero, M., Voortman, T., Riley, L., Cowan, M., Savin, S., Bennett, J., Stevens, G., Paciorek, C., Aekplakorn, W., Cifkova, R., Giampaoli, S., Kengne, A., Khang, Y., Kuulasmaa, K., Laxmaiah, A., Margozzini, P., Mathur, P., Nordestgaard, B., Zhao, D., Aadahl, M., Abarca-Gómez, L., Rahim, H., Abu-Rmeileh, N., Acosta-Cazares, B., Adams, R., Agdeppa, I., Aghazadeh-Attari, J., Aguilar-Salinas, C., Agyemang, C., Ahluwalia, T., Ahmad, N., Ahmadi, A., Ahmadi, N., Ahmed, S., Ahrens, W., Ajlouni, K., Alarouj, M., AlBuhairan, F., AlDhukair, S., Ali, M., Alkandari, A., Alkerwi, A., Aly, E., Amarapurkar, D., Amouyel, P., Andersen, L., Anderssen, S., Anjana, R., Ansari-Moghaddam, A., Aounallah-Skhiri, H., Araújo, J., Ariansen, I., Aris, T., Arku, R., Arlappa, N., Aryal, K., Aspelund, T., Assunção, M., Auvinen, J., Avdicová, M., Azevedo, A., Azizi, F., Azmin, M., Balakrishna, N., Bamoshmoosh, M., Banach, M., Bandosz, P., Banegas, J., Barbagallo, C., Barceló, A., Barkat, A., Bata, I., Batieha, A., Batyrbek, A., Baur, L., Beaglehole, R., Belavendra, A., Ben Romdhane, H., Benet, M., Benn, M., Berkinbayev, S., Bernabe-Ortiz, A., Bernotiene, G., Bettiol, H., Bhargava, S., Bi, Y., Bienek, A., Bikbov, M., Bista, B., Bjerregaard, P., Bjertness, E., Bjertness, M., Björkelund, C., Bloch, K., Blokstra, A., Bo, S., Boehm, B., Boggia, J., Boissonnet, C., Bonaccio, M., Bongard, V., Borchini, R., Borghs, H., Bovet, P., Brajkovich, I., Breckenkamp, J., Brenner, H., Brewster, L., Bruno, G., Bugge, A., Busch, M., de León, A., Cacciottolo, J., Can, G., Cândido, A., Capanzana, M., Capuano, E., Capuano, V., Cardoso, V., Carvalho, J., Casanueva, F., Censi, L., Chadjigeorgiou, C., Chamukuttan, S., Chaturvedi, N., Chen, C., Chen, F., Chen, S., Cheng, C., Cheraghian, B., Chetrit, A., Chiou, S., Chirlaque, M., Cho, B., Cho, Y., Chudek, J., Claessens, F., Clarke, J., Clays, E., Concin, H., Confortin, S., Cooper, C., Costanzo, S., Cottel, D., Cowell, C., Crujeiras, A., Csilla, S., Cui, L., Cureau, F., D’Arrigo, G., d’Orsi, E., Dallongeville, J., Damasceno, A., Dankner, R., Dantoft, T., Dauchet, L., Davletov, K., De Backer, G., De Bacquer, D., de Gaetano, G., De Henauw, S., de Oliveira, P., De Ridder, D., De Smedt, D., Deepa, M., Deev, A., Dehghan, A., Delisle, H., Dennison, E., Deschamps, V., Dhimal, M., Di Castelnuovo, A., Dika, Z., Djalalinia, S., Dobson, A., Donfrancesco, C., Donoso, S., Döring, A., Dorobantu, M., Dragano, N., Drygas, W., Du, Y., Duante, C., Duda, R., Dzerve, V., Dziankowska-Zaborszczyk, E., Eddie, R., Eftekhar, E., Eggertsen, R., Eghtesad, S., Eiben, G., Ekelund, U., El Ati, J., Eldemire-Shearer, D., Eliasen, M., Elosua, R., Erasmus, R., Erbel, R., Erem, C., Eriksen, L., Eriksson, J., Escobedo-de la Peña, J., Eslami, S., Esmaeili, A., Evans, A., Faeh, D., Fall, C., Faramarzi, E., Farjam, M., Fattahi, M., Felix-Redondo, F., Ferguson, T., Fernández-Bergés, D., Ferrante, D., Ferrari, M., Ferreccio, C., Ferrieres, J., Föger, B., Foo, L., Forslund, A., Forsner, M., Fouad, H., Francis, D., do Carmo Franco, M., Franco, O., Frontera, G., Fujita, Y., Fumihiko, M., Furusawa, T., Gaciong, Z., Galvano, F., Gao, J., Garcia-de-la-Hera, M., Garnett, S., Gaspoz, J., Gasull, M., Gazzinelli, A., Geleijnse, J., Ghanbari, A., Ghasemi, E., Gheorghe-Fronea, O., Ghimire, A., Gianfagna, F., Gill, T., Giovannelli, J., Gironella, G., Giwercman, A., Goltzman, D., Gonçalves, H., Gonzalez-Chica, D., Gonzalez-Gross, M., González-Rivas, J., González-Villalpando, C., González-Villalpando, M., Gonzalez, A., Gottrand, F., Graff-Iversen, S., Grafnetter, D., Gregor, R., Grodzicki, T., Grøntved, A., Grosso, G., Gruden, G., Gu, D., Guallar-Castillón, P., Guan, O., Gudmundsson, E., Gudnason, V., Guerrero, R., Guessous, I., Gunnlaugsdottir, J., Gupta, R., Gutierrez, L., Gutzwiller, F., Ha, S., Hadaegh, F., Haghshenas, R., Hakimi, H., Hambleton, I., Hamzeh, B., Hantunen, S., Kumar, R., Hashemi-Shahri, S., Hata, J., Haugsgjerd, T., Hayes, A., He, J., He, Y., Hendriks, M., Henriques, A., Herrala, S., Heshmat, R., Hill, A., Ho, S., Ho, S., Hobbs, M., Hofman, A., Homayounfar, R., Hopman, W., Horimoto, A., Hormiga, C., Horta, B., Houti, L., Howitt, C., Htay, T., Htet, A., Htike, M., Huerta, J., Huhtaniemi, I., Huisman, M., Hunsberger, M., Husseini, A., Huybrechts, I., Hwalla, N., Iacoviello, L., Iannone, A., Ibrahim, M., Wong, N., Iglesia, I., Ikeda, N., Ikram, M., Iotova, V., Irazola, V., Ishida, T., Islam, M., al-Safi Ismail, A., Iwasaki, M., Jacobs, J., Jaddou, H., Jafar, T., James, K., Jamrozik, K., Janszky, I., Janus, E., Jarvelin, M., Jasienska, G., Jelakovic, A., Jelakovic, B., Jennings, G., Jensen, G., Jeong, S., Jha, A., Jiang, C., Jimenez, R., Jöckel, K., Joffres, M., Jokelainen, J., Jonas, J., Jørgensen, T., Joshi, P., Joukar, F., Józwiak, J., Juolevi, A., Kafatos, A., Kajantie, E., Kalter-Leibovici, O., Kamaruddin, N., Kamstrup, P., Karki, K., Katz, J., Kauhanen, J., Kaur, P., Kavousi, M., Kazakbaeva, G., Keil, U., Keinänen-Kiukaanniemi, S., Kelishadi, R., Keramati, M., Kerimkulova, A., Kersting, M., Khader, Y., Khalili, D., Khateeb, M., Kheradmand, M., Khosravi, A., Kiechl-Kohlendorfer, U., Kiechl, S., Killewo, J., Kim, H., Kim, J., Kim, Y., Klumbiene, J., Knoflach, M., Ko, S., Kohler, H., Kohler, I., Kolle, E., Kolsteren, P., König, J., Korpelainen, R., Korrovits, P., Kos, J., Koskinen, S., Kouda, K., Kowlessur, S., Kratzer, W., Kriemler, S., Kristensen, P., Krokstad, S., Kromhout, D., Kujala, U., Kurjata, P., Kyobutungi, C., Laamiri, F., Laatikainen, T., Lachat, C., Laid, Y., Lam, T., Lambrinou, C., Lanska, V., Lappas, G., Larijani, B., Latt, T., Laugsand, L., Lazo-Porras, M., Lee, J., Lee, J., Lehmann, N., Lehtimäki, T., Levitt, N., Li, Y., Lilly, C., Lim, W., Lima-Costa, M., Lin, H., Lin, X., Lin, Y., Lind, L., Linneberg, A., Lissner, L., Liu, J., Loit, H., Lopez-Garcia, E., Lopez, T., Lotufo, P., Lozano, J., Luksiene, D., Lundqvist, A., Lundqvist, R., Lunet, N., Ma, G., Machado-Coelho, G., Machado-Rodrigues, A., Machi, S., Madar, A., Maggi, S., Magliano, D., Magriplis, E., Mahasampath, G., Maire, B., Makdisse, M., Malekzadeh, F., Malekzadeh, R., Rao, K., Manios, Y., Mann, J., Mansour-Ghanaei, F., Manzato, E., Marques-Vidal, P., Martorell, R., Mascarenhas, L., Mathiesen, E., Matsha, T., Mavrogianni, C., McFarlane, S., McGarvey, S., McLachlan, S., McLean, R., McLean, S., McNulty, B., Mediene-Benchekor, S., Mehdipour, P., Mehlig, K., Mehrparvar, A., Meirhaeghe, A., Meisinger, C., Menezes, A., Menon, G., Merat, S., Mereke, A., Meshram, I., Metcalf, P., Meyer, H., Mi, J., Michels, N., Miller, J., Minderico, C., Mini, G., Miquel, J., Miranda, J., Mirjalili, M., Mirrakhimov, E., Modesti, P., Moghaddam, S., Mohajer, B., Mohamed, M., Mohammad, K., Mohammadi, Z., Mohammadifard, N., Mohammadpourhodki, R., Mohan, V., Mohanna, S., Yusoff, M., Mohebbi, I., Mohebi, F., Moitry, M., Møllehave, L., Møller, N., Molnár, D., Momenan, A., Mondo, C., Monterrubio-Flores, E., Moosazadeh, M., Morejon, A., Moreno, L., Morgan, K., Morin, S., Moschonis, G., Mossakowska, M., Mostafa, A., Mota, J., Motlagh, M., Motta, J., Msyamboza, K., Muiesan, M., Müller-Nurasyid, M., Mursu, J., Mustafa, N., Nabipour, I., Naderimagham, S., Nagel, G., Naidu, B., Najafi, F., Nakamura, H., Námešná, J., Nang, E., Nangia, V., Nauck, M., Neal, W., Nejatizadeh, A., Nenko, I., Nervi, F., Nguyen, N., Nguyen, Q., Nieto-Martínez, R., Nihal, T., Niiranen, T., Ning, G., Ninomiya, T., Noale, M., Noboa, O., Noto, D., Nsour, M., Nuhoğlu, I., O’Neill, T., O’Reilly, D., Ochoa-Avilés, A., Oh, K., Ohtsuka, R., Olafsson, Ö., Olié, V., Oliveira, I., Omar, M., Onat, A., Ong, S., Ordunez, P., Ornelas, R., Ortiz, P., Osmond, C., Ostojic, S., Ostovar, A., Otero, J., Owusu-Dabo, E., Paccaud, F., Pahomova, E., Pajak, A., Palmieri, L., Pan, W., Panda-Jonas, S., Panza, F., Parnell, W., Patel, N., Peer, N., Peixoto, S., Peltonen, M., Pereira, A., Peters, A., Petersmann, A., Petkeviciene, J., Peykari, N., Pham, S., Pichardo, R., Pigeot, I., Pilav, A., Pilotto, L., Piwonska, A., Pizarro, A., Plans-Rubió, P., Plata, S., Pohlabeln, H., Porta, M., Portegies, M., Poudyal, A., Pourfarzi, F., Poustchi, H., Pradeepa, R., Price, J., Providencia, R., Puder, J., Puhakka, S., Punab, M., Qorbani, M., Bao, T., Radisauskas, R., Rahimikazerooni, S., Raitakari, O., Rao, S., Ramachandran, A., Ramos, E., Ramos, R., Rampal, L., Rampal, S., Redon, J., Reganit, P., Revilla, L., Rezaianzadeh, A., Ribeiro, R., Richter, A., Rigo, F., Rinke de Wit, T., Rodríguez-Artalejo, F., del Cristo Rodriguez-Perez, M., Rodríguez-Villamizar, L., Roggenbuck, U., Rojas-Martinez, R., Romaguera, D., Romeo, E., Rosengren, A., Roy, J., Rubinstein, A., Ruidavets, J., Ruiz-Betancourt, B., Russo, P., Rust, P., Rutkowski, M., Sabanayagam, C., Sachdev, H., Sadjadi, A., Safarpour, A., Safiri, S., Saidi, O., Saki, N., Salanave, B., Salmerón, D., Salomaa, V., Salonen, J., Salvetti, M., Sánchez-Abanto, J., Sans, S., Santaliestra-Pasías, A., Santos, D., Santos, M., Santos, R., Saramies, J., Sardinha, L., Sarrafzadegan, N., Saum, K., Savva, S., Sawada, N., Sbaraini, M., Scazufca, M., Schaan, B., Schargrodsky, H., Scheidt-Nave, C., Schienkiewitz, A., Schipf, S., Schmidt, C., Schöttker, B., Schramm, S., Sebert, S., Sein, A., Sen, A., Sepanlou, S., Servais, J., Shakeri, R., Shalnova, S., Shamah-Levy, T., Sharafkhah, M., Sharma, S., Shaw, J., Shayanrad, A., Shi, Z., Shibuya, K., Shimizu-Furusawa, H., Shin, D., Shin, Y., Shirani, M., Shiri, R., Shrestha, N., Si-Ramlee, K., Siani, A., Siantar, R., Sibai, A., Silva, D., Simon, M., Simons, J., Simons, L., Sjöström, M., Skaaby, T., Slowikowska-Hilczer, J., Slusarczyk, P., Smeeth, L., Snijder, M., Söderberg, S., Soemantri, A., Sofat, R., Solfrizzi, V., Somi, M., Sonestedt, E., Sørensen, T., Jérome, C., Soumaré, A., Sozmen, K., Sparrenberger, K., Staessen, J., Stathopoulou, M., Stavreski, B., Steene-Johannessen, J., Stehle, P., Stein, A., Stessman, J., Stevanović, R., Stieber, J., Stöckl, D., Stokwiszewski, J., Stronks, K., Strufaldi, M., Suárez-Medina, R., Sun, C., Sundström, J., Suriyawongpaisal, P., Sy, R., Sylva, R., Szklo, M., Tai, E., Tamosiunas, A., Tan, E., Tarawneh, M., Tarqui-Mamani, C., Taylor, A., Taylor, J., Tell, G., Tello, T., Thankappan, K., Thijs, L., Thuesen, B., Toft, U., Tolonen, H., Tolstrup, J., Topbas, M., Topór-Madry, R., Tormo, M., Tornaritis, M., Torrent, M., Torres-Collado, L., Traissac, P., Trinh, O., Truthmann, J., Tsugane, S., Tulloch-Reid, M., Tuomainen, T., Tuomilehto, J., Tybjaerg-Hansen, A., Tzourio, C., Ueda, P., Ugel, E., Ulmer, H., Unal, B., Uusitalo, H., Valdivia, G., Valvi, D., van Dam, R., van der Schouw, Y., Van Herck, K., Van Minh, H., van Rossem, L., Van Schoor, N., van Valkengoed, I., Vanderschueren, D., Vanuzzo, D., Varbo, A., Varona-Pérez, P., Vasan, S., Vatten, L., Vega, T., Veidebaum, T., Velasquez-Melendez, G., Venero-Fernández, S., Veronesi, G., Verschuren, W., Victora, C., Vidiawati, D., Viet, L., Villalpando, S., Vioque, J., Virtanen, J., Visvikis-Siest, S., Viswanathan, B., Vlasoff, T., Vollenweider, P., Voutilainen, A., Wade, A., Wagner, A., Walton, J., Bebakar, W., Mohamud, W., Wang, M., Wang, N., Wang, Q., Wang, Y., Wang, Y., Wannamethee, S., Wedderkopp, N., Wei, W., Whincup, P., Widhalm, K., Widyahening, I., Wiecek, A., Wijga, A., Wilks, R., Willeit, J., Willeit, P., Wilsgaard, T., Wojtyniak, B., Wong-McClure, R., Wong, A., Wong, T., Woo, J., Woodward, M., Wu, F., Wu, S., Xu, H., Xu, L., Yan, W., Yang, X., Yasuharu, T., Ye, X., Yeow, T., Yiallouros, P., Yoosefi, M., Yoshihara, A., You, S., Younger-Coleman, N., Yusoff, A., Zainuddin, A., Zakavi, S., Zali, M., Zamani, F., Zambon, S., Zampelas, A., Zaw, K., Zdrojewski, T., Vrkic, T., Zhang, Z., Zhao, W., Zhen, S., Zheng, Y., Zholdin, B., Zhussupov, B., Zoghlami, N., Cisneros, J., Gregg, E. and Ezzati, M. 2020. Repositioning of the global epicentre of non-optimal cholesterol. Nature. 582 (7810), pp. 73-77. https://doi.org/10.1038/s41586-020-2338-1
TypeArticle
TitleRepositioning of the global epicentre of non-optimal cholesterol
AuthorsNCD Risk Factor Collaboration (NCD-RisC), Taddei, C., Zhou, B., Bixby, H., Carrillo-Larco, R., Danaei, G., Jackson, R., Farzadfar, F., Sophiea, M., Di Cesare, M., Iurilli, M., Martinez, A., Asghari, G., Dhana, K., Gulayin, P., Kakarmath, S., Santero, M., Voortman, T., Riley, L., Cowan, M., Savin, S., Bennett, J., Stevens, G., Paciorek, C., Aekplakorn, W., Cifkova, R., Giampaoli, S., Kengne, A., Khang, Y., Kuulasmaa, K., Laxmaiah, A., Margozzini, P., Mathur, P., Nordestgaard, B., Zhao, D., Aadahl, M., Abarca-Gómez, L., Rahim, H., Abu-Rmeileh, N., Acosta-Cazares, B., Adams, R., Agdeppa, I., Aghazadeh-Attari, J., Aguilar-Salinas, C., Agyemang, C., Ahluwalia, T., Ahmad, N., Ahmadi, A., Ahmadi, N., Ahmed, S., Ahrens, W., Ajlouni, K., Alarouj, M., AlBuhairan, F., AlDhukair, S., Ali, M., Alkandari, A., Alkerwi, A., Aly, E., Amarapurkar, D., Amouyel, P., Andersen, L., Anderssen, S., Anjana, R., Ansari-Moghaddam, A., Aounallah-Skhiri, H., Araújo, J., Ariansen, I., Aris, T., Arku, R., Arlappa, N., Aryal, K., Aspelund, T., Assunção, M., Auvinen, J., Avdicová, M., Azevedo, A., Azizi, F., Azmin, M., Balakrishna, N., Bamoshmoosh, M., Banach, M., Bandosz, P., Banegas, J., Barbagallo, C., Barceló, A., Barkat, A., Bata, I., Batieha, A., Batyrbek, A., Baur, L., Beaglehole, R., Belavendra, A., Ben Romdhane, H., Benet, M., Benn, M., Berkinbayev, S., Bernabe-Ortiz, A., Bernotiene, G., Bettiol, H., Bhargava, S., Bi, Y., Bienek, A., Bikbov, M., Bista, B., Bjerregaard, P., Bjertness, E., Bjertness, M., Björkelund, C., Bloch, K., Blokstra, A., Bo, S., Boehm, B., Boggia, J., Boissonnet, C., Bonaccio, M., Bongard, V., Borchini, R., Borghs, H., Bovet, P., Brajkovich, I., Breckenkamp, J., Brenner, H., Brewster, L., Bruno, G., Bugge, A., Busch, M., de León, A., Cacciottolo, J., Can, G., Cândido, A., Capanzana, M., Capuano, E., Capuano, V., Cardoso, V., Carvalho, J., Casanueva, F., Censi, L., Chadjigeorgiou, C., Chamukuttan, S., Chaturvedi, N., Chen, C., Chen, F., Chen, S., Cheng, C., Cheraghian, B., Chetrit, A., Chiou, S., Chirlaque, M., Cho, B., Cho, Y., Chudek, J., Claessens, F., Clarke, J., Clays, E., Concin, H., Confortin, S., Cooper, C., Costanzo, S., Cottel, D., Cowell, C., Crujeiras, A., Csilla, S., Cui, L., Cureau, F., D’Arrigo, G., d’Orsi, E., Dallongeville, J., Damasceno, A., Dankner, R., Dantoft, T., Dauchet, L., Davletov, K., De Backer, G., De Bacquer, D., de Gaetano, G., De Henauw, S., de Oliveira, P., De Ridder, D., De Smedt, D., Deepa, M., Deev, A., Dehghan, A., Delisle, H., Dennison, E., Deschamps, V., Dhimal, M., Di Castelnuovo, A., Dika, Z., Djalalinia, S., Dobson, A., Donfrancesco, C., Donoso, S., Döring, A., Dorobantu, M., Dragano, N., Drygas, W., Du, Y., Duante, C., Duda, R., Dzerve, V., Dziankowska-Zaborszczyk, E., Eddie, R., Eftekhar, E., Eggertsen, R., Eghtesad, S., Eiben, G., Ekelund, U., El Ati, J., Eldemire-Shearer, D., Eliasen, M., Elosua, R., Erasmus, R., Erbel, R., Erem, C., Eriksen, L., Eriksson, J., Escobedo-de la Peña, J., Eslami, S., Esmaeili, A., Evans, A., Faeh, D., Fall, C., Faramarzi, E., Farjam, M., Fattahi, M., Felix-Redondo, F., Ferguson, T., Fernández-Bergés, D., Ferrante, D., Ferrari, M., Ferreccio, C., Ferrieres, J., Föger, B., Foo, L., Forslund, A., Forsner, M., Fouad, H., Francis, D., do Carmo Franco, M., Franco, O., Frontera, G., Fujita, Y., Fumihiko, M., Furusawa, T., Gaciong, Z., Galvano, F., Gao, J., Garcia-de-la-Hera, M., Garnett, S., Gaspoz, J., Gasull, M., Gazzinelli, A., Geleijnse, J., Ghanbari, A., Ghasemi, E., Gheorghe-Fronea, O., Ghimire, A., Gianfagna, F., Gill, T., Giovannelli, J., Gironella, G., Giwercman, A., Goltzman, D., Gonçalves, H., Gonzalez-Chica, D., Gonzalez-Gross, M., González-Rivas, J., González-Villalpando, C., González-Villalpando, M., Gonzalez, A., Gottrand, F., Graff-Iversen, S., Grafnetter, D., Gregor, R., Grodzicki, T., Grøntved, A., Grosso, G., Gruden, G., Gu, D., Guallar-Castillón, P., Guan, O., Gudmundsson, E., Gudnason, V., Guerrero, R., Guessous, I., Gunnlaugsdottir, J., Gupta, R., Gutierrez, L., Gutzwiller, F., Ha, S., Hadaegh, F., Haghshenas, R., Hakimi, H., Hambleton, I., Hamzeh, B., Hantunen, S., Kumar, R., Hashemi-Shahri, S., Hata, J., Haugsgjerd, T., Hayes, A., He, J., He, Y., Hendriks, M., Henriques, A., Herrala, S., Heshmat, R., Hill, A., Ho, S., Ho, S., Hobbs, M., Hofman, A., Homayounfar, R., Hopman, W., Horimoto, A., Hormiga, C., Horta, B., Houti, L., Howitt, C., Htay, T., Htet, A., Htike, M., Huerta, J., Huhtaniemi, I., Huisman, M., Hunsberger, M., Husseini, A., Huybrechts, I., Hwalla, N., Iacoviello, L., Iannone, A., Ibrahim, M., Wong, N., Iglesia, I., Ikeda, N., Ikram, M., Iotova, V., Irazola, V., Ishida, T., Islam, M., al-Safi Ismail, A., Iwasaki, M., Jacobs, J., Jaddou, H., Jafar, T., James, K., Jamrozik, K., Janszky, I., Janus, E., Jarvelin, M., Jasienska, G., Jelakovic, A., Jelakovic, B., Jennings, G., Jensen, G., Jeong, S., Jha, A., Jiang, C., Jimenez, R., Jöckel, K., Joffres, M., Jokelainen, J., Jonas, J., Jørgensen, T., Joshi, P., Joukar, F., Józwiak, J., Juolevi, A., Kafatos, A., Kajantie, E., Kalter-Leibovici, O., Kamaruddin, N., Kamstrup, P., Karki, K., Katz, J., Kauhanen, J., Kaur, P., Kavousi, M., Kazakbaeva, G., Keil, U., Keinänen-Kiukaanniemi, S., Kelishadi, R., Keramati, M., Kerimkulova, A., Kersting, M., Khader, Y., Khalili, D., Khateeb, M., Kheradmand, M., Khosravi, A., Kiechl-Kohlendorfer, U., Kiechl, S., Killewo, J., Kim, H., Kim, J., Kim, Y., Klumbiene, J., Knoflach, M., Ko, S., Kohler, H., Kohler, I., Kolle, E., Kolsteren, P., König, J., Korpelainen, R., Korrovits, P., Kos, J., Koskinen, S., Kouda, K., Kowlessur, S., Kratzer, W., Kriemler, S., Kristensen, P., Krokstad, S., Kromhout, D., Kujala, U., Kurjata, P., Kyobutungi, C., Laamiri, F., Laatikainen, T., Lachat, C., Laid, Y., Lam, T., Lambrinou, C., Lanska, V., Lappas, G., Larijani, B., Latt, T., Laugsand, L., Lazo-Porras, M., Lee, J., Lee, J., Lehmann, N., Lehtimäki, T., Levitt, N., Li, Y., Lilly, C., Lim, W., Lima-Costa, M., Lin, H., Lin, X., Lin, Y., Lind, L., Linneberg, A., Lissner, L., Liu, J., Loit, H., Lopez-Garcia, E., Lopez, T., Lotufo, P., Lozano, J., Luksiene, D., Lundqvist, A., Lundqvist, R., Lunet, N., Ma, G., Machado-Coelho, G., Machado-Rodrigues, A., Machi, S., Madar, A., Maggi, S., Magliano, D., Magriplis, E., Mahasampath, G., Maire, B., Makdisse, M., Malekzadeh, F., Malekzadeh, R., Rao, K., Manios, Y., Mann, J., Mansour-Ghanaei, F., Manzato, E., Marques-Vidal, P., Martorell, R., Mascarenhas, L., Mathiesen, E., Matsha, T., Mavrogianni, C., McFarlane, S., McGarvey, S., McLachlan, S., McLean, R., McLean, S., McNulty, B., Mediene-Benchekor, S., Mehdipour, P., Mehlig, K., Mehrparvar, A., Meirhaeghe, A., Meisinger, C., Menezes, A., Menon, G., Merat, S., Mereke, A., Meshram, I., Metcalf, P., Meyer, H., Mi, J., Michels, N., Miller, J., Minderico, C., Mini, G., Miquel, J., Miranda, J., Mirjalili, M., Mirrakhimov, E., Modesti, P., Moghaddam, S., Mohajer, B., Mohamed, M., Mohammad, K., Mohammadi, Z., Mohammadifard, N., Mohammadpourhodki, R., Mohan, V., Mohanna, S., Yusoff, M., Mohebbi, I., Mohebi, F., Moitry, M., Møllehave, L., Møller, N., Molnár, D., Momenan, A., Mondo, C., Monterrubio-Flores, E., Moosazadeh, M., Morejon, A., Moreno, L., Morgan, K., Morin, S., Moschonis, G., Mossakowska, M., Mostafa, A., Mota, J., Motlagh, M., Motta, J., Msyamboza, K., Muiesan, M., Müller-Nurasyid, M., Mursu, J., Mustafa, N., Nabipour, I., Naderimagham, S., Nagel, G., Naidu, B., Najafi, F., Nakamura, H., Námešná, J., Nang, E., Nangia, V., Nauck, M., Neal, W., Nejatizadeh, A., Nenko, I., Nervi, F., Nguyen, N., Nguyen, Q., Nieto-Martínez, R., Nihal, T., Niiranen, T., Ning, G., Ninomiya, T., Noale, M., Noboa, O., Noto, D., Nsour, M., Nuhoğlu, I., O’Neill, T., O’Reilly, D., Ochoa-Avilés, A., Oh, K., Ohtsuka, R., Olafsson, Ö., Olié, V., Oliveira, I., Omar, M., Onat, A., Ong, S., Ordunez, P., Ornelas, R., Ortiz, P., Osmond, C., Ostojic, S., Ostovar, A., Otero, J., Owusu-Dabo, E., Paccaud, F., Pahomova, E., Pajak, A., Palmieri, L., Pan, W., Panda-Jonas, S., Panza, F., Parnell, W., Patel, N., Peer, N., Peixoto, S., Peltonen, M., Pereira, A., Peters, A., Petersmann, A., Petkeviciene, J., Peykari, N., Pham, S., Pichardo, R., Pigeot, I., Pilav, A., Pilotto, L., Piwonska, A., Pizarro, A., Plans-Rubió, P., Plata, S., Pohlabeln, H., Porta, M., Portegies, M., Poudyal, A., Pourfarzi, F., Poustchi, H., Pradeepa, R., Price, J., Providencia, R., Puder, J., Puhakka, S., Punab, M., Qorbani, M., Bao, T., Radisauskas, R., Rahimikazerooni, S., Raitakari, O., Rao, S., Ramachandran, A., Ramos, E., Ramos, R., Rampal, L., Rampal, S., Redon, J., Reganit, P., Revilla, L., Rezaianzadeh, A., Ribeiro, R., Richter, A., Rigo, F., Rinke de Wit, T., Rodríguez-Artalejo, F., del Cristo Rodriguez-Perez, M., Rodríguez-Villamizar, L., Roggenbuck, U., Rojas-Martinez, R., Romaguera, D., Romeo, E., Rosengren, A., Roy, J., Rubinstein, A., Ruidavets, J., Ruiz-Betancourt, B., Russo, P., Rust, P., Rutkowski, M., Sabanayagam, C., Sachdev, H., Sadjadi, A., Safarpour, A., Safiri, S., Saidi, O., Saki, N., Salanave, B., Salmerón, D., Salomaa, V., Salonen, J., Salvetti, M., Sánchez-Abanto, J., Sans, S., Santaliestra-Pasías, A., Santos, D., Santos, M., Santos, R., Saramies, J., Sardinha, L., Sarrafzadegan, N., Saum, K., Savva, S., Sawada, N., Sbaraini, M., Scazufca, M., Schaan, B., Schargrodsky, H., Scheidt-Nave, C., Schienkiewitz, A., Schipf, S., Schmidt, C., Schöttker, B., Schramm, S., Sebert, S., Sein, A., Sen, A., Sepanlou, S., Servais, J., Shakeri, R., Shalnova, S., Shamah-Levy, T., Sharafkhah, M., Sharma, S., Shaw, J., Shayanrad, A., Shi, Z., Shibuya, K., Shimizu-Furusawa, H., Shin, D., Shin, Y., Shirani, M., Shiri, R., Shrestha, N., Si-Ramlee, K., Siani, A., Siantar, R., Sibai, A., Silva, D., Simon, M., Simons, J., Simons, L., Sjöström, M., Skaaby, T., Slowikowska-Hilczer, J., Slusarczyk, P., Smeeth, L., Snijder, M., Söderberg, S., Soemantri, A., Sofat, R., Solfrizzi, V., Somi, M., Sonestedt, E., Sørensen, T., Jérome, C., Soumaré, A., Sozmen, K., Sparrenberger, K., Staessen, J., Stathopoulou, M., Stavreski, B., Steene-Johannessen, J., Stehle, P., Stein, A., Stessman, J., Stevanović, R., Stieber, J., Stöckl, D., Stokwiszewski, J., Stronks, K., Strufaldi, M., Suárez-Medina, R., Sun, C., Sundström, J., Suriyawongpaisal, P., Sy, R., Sylva, R., Szklo, M., Tai, E., Tamosiunas, A., Tan, E., Tarawneh, M., Tarqui-Mamani, C., Taylor, A., Taylor, J., Tell, G., Tello, T., Thankappan, K., Thijs, L., Thuesen, B., Toft, U., Tolonen, H., Tolstrup, J., Topbas, M., Topór-Madry, R., Tormo, M., Tornaritis, M., Torrent, M., Torres-Collado, L., Traissac, P., Trinh, O., Truthmann, J., Tsugane, S., Tulloch-Reid, M., Tuomainen, T., Tuomilehto, J., Tybjaerg-Hansen, A., Tzourio, C., Ueda, P., Ugel, E., Ulmer, H., Unal, B., Uusitalo, H., Valdivia, G., Valvi, D., van Dam, R., van der Schouw, Y., Van Herck, K., Van Minh, H., van Rossem, L., Van Schoor, N., van Valkengoed, I., Vanderschueren, D., Vanuzzo, D., Varbo, A., Varona-Pérez, P., Vasan, S., Vatten, L., Vega, T., Veidebaum, T., Velasquez-Melendez, G., Venero-Fernández, S., Veronesi, G., Verschuren, W., Victora, C., Vidiawati, D., Viet, L., Villalpando, S., Vioque, J., Virtanen, J., Visvikis-Siest, S., Viswanathan, B., Vlasoff, T., Vollenweider, P., Voutilainen, A., Wade, A., Wagner, A., Walton, J., Bebakar, W., Mohamud, W., Wang, M., Wang, N., Wang, Q., Wang, Y., Wang, Y., Wannamethee, S., Wedderkopp, N., Wei, W., Whincup, P., Widhalm, K., Widyahening, I., Wiecek, A., Wijga, A., Wilks, R., Willeit, J., Willeit, P., Wilsgaard, T., Wojtyniak, B., Wong-McClure, R., Wong, A., Wong, T., Woo, J., Woodward, M., Wu, F., Wu, S., Xu, H., Xu, L., Yan, W., Yang, X., Yasuharu, T., Ye, X., Yeow, T., Yiallouros, P., Yoosefi, M., Yoshihara, A., You, S., Younger-Coleman, N., Yusoff, A., Zainuddin, A., Zakavi, S., Zali, M., Zamani, F., Zambon, S., Zampelas, A., Zaw, K., Zdrojewski, T., Vrkic, T., Zhang, Z., Zhao, W., Zhen, S., Zheng, Y., Zholdin, B., Zhussupov, B., Zoghlami, N., Cisneros, J., Gregg, E. and Ezzati, M.
Abstract

High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.

KeywordsCardiovascular diseases, Risk factors
PublisherNature Publishing Group
JournalNature
ISSN0028-0836
Electronic1476-4687
Publication dates
Online03 Jun 2020
Print04 Jun 2020
Publication process dates
Deposited04 Jun 2020
Submitted18 Oct 2019
Accepted02 Apr 2020
Output statusPublished
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Any methods, additional references, Nature Research reporting summaries, source data, extended data, supplementary information, acknowledgements, peer review information; details of author contributions and competing interests; and statements of data and code availability are available at https://doi.org/10.1038/s41586-020-2338-1
[see also the useful links section of this record for Data or Supplementary Material links]

Digital Object Identifier (DOI)https://doi.org/10.1038/s41586-020-2338-1
LanguageEnglish
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