Comparative selection strategies for development of platinum-drug resistant ovarian cancer cell lines
Conference item
Busschots, S., Kalachand, R., O'Toole, S., O'Leary, J., Hennessy, B. and Stordal, B. 2017. Comparative selection strategies for development of platinum-drug resistant ovarian cancer cell lines. 12th International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy. Sydney, Australia 10 - 14 Dec 2017
Title | Comparative selection strategies for development of platinum-drug resistant ovarian cancer cell lines |
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Authors | Busschots, S., Kalachand, R., O'Toole, S., O'Leary, J., Hennessy, B. and Stordal, B. |
Abstract | The development of a drug-resistant cell line in vitro can take from 3 to 18 months. However, little is published on the methodology of this development process. Clinically relevant drug-resistant cell lines are developed by mimicking the conditions cancer patients experience during chemotherapy Doses of drug administered are low, and a pulsed treatment strategy is often used where the cells recover in drug-free media. It is common to have difficulty developing stable clinically relevant drug-resistant cell lines. A comparative selection strategy of multiple cell lines or multiple chemotherapeutic agents mitigates this risk and gives insight into which agents or which clinical phenotypes develops resistance easily. |
Sustainable Development Goals | 3 Good health and well-being |
Research Group | Biomarkers for Cancer group |
Conference | 12th International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy |
Publication dates | |
14 Dec 2017 | |
Publication process dates | |
Deposited | 07 Jul 2022 |
Accepted | 16 Nov 2017 |
Output status | Published |
Language | English |
https://repository.mdx.ac.uk/item/89x68
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