Ovarian cancer: identifying and managing familial and genetic risk

Project report

Slade, E., Berg, L., Dworzynski, K., Manchanda, R., Barber, V., Bowen, R., Brentnall, A., Cameron, A., Davies, D., Davies, M., Evans, D., Hayward, J., McCluggage, W., Miles, T., Monahan, K., Moses, D., Robb, F., Rosenthal, A., Side, L., Stanford, J., Stordal, B. and Tripathi, V. 2024. Ovarian cancer: identifying and managing familial and genetic risk. National Institute for Health and Care Excellence.
TypeProject report
TitleOvarian cancer: identifying and managing familial and genetic risk
AuthorsSlade, E., Berg, L., Dworzynski, K., Manchanda, R., Barber, V., Bowen, R., Brentnall, A., Cameron, A., Davies, D., Davies, M., Evans, D., Hayward, J., McCluggage, W., Miles, T., Monahan, K., Moses, D., Robb, F., Rosenthal, A., Side, L., Stanford, J., Stordal, B. and Tripathi, V.
Abstract

This guideline covers assessing the familial and genetic risk of having a pathogenic variant associated with ovarian cancer in adults.

In women, trans men and non-binary people with female reproductive organs (ovaries, fallopian tubes and/or a uterus), having a pathogenic variant increases the risk of developing ovarian cancer (familial ovarian cancer). As well as risk assessment, this guideline covers risk management and decision-making support for people born with female reproductive organs who have, or are at risk of having, a pathogenic variant associated with ovarian cancer.

Men, trans women and non-binary people born with male reproductive organs cannot develop ovarian cancer, but if they have a pathogenic variant associated with ovarian cancer, they can pass the variant on to their children, and may be at risk of developing other cancers. This guideline covers risk assessment, but it does not cover managing risk or decision-making support for people born with male reproductive organs.

NICE has also produced a guideline on the recognition and initial management of ovarian cancer.

Sustainable Development Goals3 Good health and well-being
Middlesex University ThemeHealth & Wellbeing
Research GroupBiomarkers for Cancer group
PublisherNational Institute for Health and Care Excellence
Publication dates
Print21 Mar 2024
Publication process dates
Accepted21 Mar 2024
Deposited10 May 2024
Output statusPublished
Additional information

NICE guideline [NG241]

Web address (URL)https://www.nice.org.uk/guidance/NG241
LanguageEnglish
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