A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship

Article

Stordal, B., Pavlakis, N. and Davey, R. 2007. A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship. Cancer Treatment Reviews. 33 (8), pp. 688-703. https://doi.org/10.1016/j.ctrv.2007.07.013
TypeArticle
TitleA systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship
AuthorsStordal, B., Pavlakis, N. and Davey, R.
Abstract

We undertook a systematic review of the pre-clinical and clinical literature for studies investigating the relationship between platinum and taxane resistance. Medline was searched for (1) cell models of acquired drug resistance reporting platinum and taxane sensitivities and (2) clinical trials of platinum or taxane salvage therapy in ovarian cancer. One hundred and thirty-seven models of acquired drug resistance were identified. 68.1% of cisplatin-resistant cells were sensitive to paclitaxel and 66.7% of paclitaxel-resistant cells were sensitive to cisplatin. A similar inverse pattern was observed for cisplatin vs. docetaxel, carboplatin vs. paclitaxel and carboplatin vs. docetaxel. These associations were independent of cancer type, agents used to develop resistance and reported mechanisms of resistance. Sixty-five eligible clinical trials of paclitaxel-based salvage after platinum therapy were identified. Studies of single agent paclitaxel in platinum-resistant ovarian cancer where patients had previously recieved paclitaxel had a pooled response rate of 35.3%, n=232, compared to 22% in paclitaxel naïve patients n=1918 (p<0.01, Chi-squared). Suggesting that pre-treatment with paclitaxel may improve the response of salvage paclitaxel therapy. The response rate to paclitaxel/platinum combination regimens in platinum-sensitive ovarian cancer was 79.5%, n=88 compared to 49.4%, n=85 for paclitaxel combined with other agents (p<0.001, Chi-squared), suggesting a positive interaction between taxanes and platinum. Therefore, the inverse relationship between platinum and taxanes resistance seen in cell models is mirrored in the clinical response to these agents in ovarian cancer. An understanding of the cellular and molecular mechanisms responsible would be valuable in predicting response to salvage chemotherapy and may identify new therapeutic targets.

Keywordscisplatin; carboplatin; paclitaxel; docetaxel; resistance; sensitivity; cross-resistance; ovarian cancer
Research GroupBiomarkers for Cancer group
PublisherElsevier
JournalCancer Treatment Reviews
ISSN0305-7372
Electronic1532-1967
Publication dates
Online20 Sep 2007
PrintDec 2007
Publication process dates
Deposited08 Jan 2016
Accepted21 Jul 2007
Output statusPublished
Accepted author manuscript
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Copyright Statement

© 2007. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
Attached is an author accepted manuscript version of an article, made available in this repository in accordance with the publisher's self-archiving policy. The final published version of the article appears in Cancer Treatment Reviews at http://dx.doi.org/10.1016/j.ctrv.2007.07.013

Web address (URL)https://www.sciencedirect.com/science/article/pii/S0305737207000989
Digital Object Identifier (DOI)https://doi.org/10.1016/j.ctrv.2007.07.013
PubMed ID17881133
Web of Science identifierWOS:000251512600003
LanguageEnglish
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