Ovarian cancer: identifying and managing familial and genetic risk—summary of new NICE guidance

Article

Slade, E., Berg, L., Dworzynski, K., Manchanda, R., Barber, V., Bowen, R., Brentnall, A., Cameron, A., Davies, D., Davies, M., Evans, D., Hayward, J., McCluggage, W., Miles, T., Monahan, K., Moses, D., Robb, F., Rosenthal, A., Side, L., Stanford, J., Stordal, B. and Tripathi, V. 2024. Ovarian cancer: identifying and managing familial and genetic risk—summary of new NICE guidance. British Medical Journal. 385. https://doi.org/10.1136/bmj.q807
TypeArticle
TitleOvarian cancer: identifying and managing familial and genetic risk—summary of new NICE guidance
AuthorsSlade, E., Berg, L., Dworzynski, K., Manchanda, R., Barber, V., Bowen, R., Brentnall, A., Cameron, A., Davies, D., Davies, M., Evans, D., Hayward, J., McCluggage, W., Miles, T., Monahan, K., Moses, D., Robb, F., Rosenthal, A., Side, L., Stanford, J., Stordal, B. and Tripathi, V.
Abstract

What you need to know
• Men and people born with male reproductive organs have a genetic risk of carrying a pathogenic variant associated with ovarian cancer and other cancers
• If a person had a direct-to-consumer genetic test and is reported to have a pathogenic variant for which NHS testing is offered, liaise with a regional NHS genetics service to discuss whether referral is appropriate
• Refer for genetic counselling and testing people who have a first or second degree relative diagnosed with ovarian cancer, those from high risk groups, anyone identified through cascade testing, or those diagnosed with ovarian cancer linked to pathogenic variants
• For women, trans men, and non-binary people born with female reproductive organs who are at increased risk of ovarian cancer, risk reducing surgery that is age appropriate for their pathogenic variant or family
history is the most effective way to reduce the risk of ovarian cancer

Sustainable Development Goals3 Good health and well-being
Middlesex University ThemeHealth & Wellbeing
Research GroupBiomarkers for Cancer group
PublisherBMJ Publishing Group Ltd
JournalBritish Medical Journal
ISSN1759-2151
Electronic0959-8138
Publication dates
Print09 May 2024
Publication process dates
Accepted09 May 2024
Deposited10 May 2024
Output statusPublished
Accepted author manuscript
File Access Level
Open
Copyright Statement

This article has been accepted for publication in The BMJ following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/bmj.q807

Additional information

Contributor roles:

Eric Slade, health economics adviser, Laura Berg, systematic reviewer, Katharina Dworzynski, guideline lead, Ranjit Manchanda, professor of gynaecological oncology and consultant gynaecological oncologist, guideline topic adviser

on behalf of the Guideline Committee:

Barber, V., Bowen, R., Brentnall, A., Cameron, A., Davies, D., Davies, M., Evans, D., Hayward, J., McCluggage, W., Miles, T., Monahan, K., Moses, D., Robb, F., Rosenthal, A., Side, L., Stanford, J., Stordal, B. and Tripathi, V.

Digital Object Identifier (DOI)https://doi.org/10.1136/bmj.q807
PubMed ID38724099
LanguageEnglish
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