Antibodies recognizing specific Mycobacterium avium subsp. paratuberculosis's MAP3738c protein in type 1 diabetes mellitus children are associated with serum Th1 (CXCL10) chemokine

Article

Cossu, A., Ferrannini, E., Fallahi, P., Antonelli, A. and Sechi, L. 2013. Antibodies recognizing specific Mycobacterium avium subsp. paratuberculosis's MAP3738c protein in type 1 diabetes mellitus children are associated with serum Th1 (CXCL10) chemokine. Cytokine. 61 (2), pp. 337-339. https://doi.org/10.1016/j.cyto.2012.11.008
TypeArticle
TitleAntibodies recognizing specific Mycobacterium avium subsp. paratuberculosis's MAP3738c protein in type 1 diabetes mellitus children are associated with serum Th1 (CXCL10) chemokine
AuthorsCossu, A., Ferrannini, E., Fallahi, P., Antonelli, A. and Sechi, L.
Abstract

Recently Mycobacterium avium subsp. paratuberculosis (Map) was associated to type 1 diabetes mellitus (T1DM). In this study we investigated for Map presence in children affected by T1DM compared to healthy children. A pool of 212 sera from T1DM children at onset was compared to sera from 57 healthy children for humoral immune response towards the Map specific protein MAP3738c by ELISA. Serum concentrations of CXCL10 (pro-Th1) and CCL2 (pro-Th2) chemokines were also measured in both sera pool. Results showed that T1DM children had a stronger seropositivity towards MAP3738c protein compared to healthy children. Data highlighted also the correlation between serum activity of T1DM patients towards the specific protein of Map and the increase of CXCL10 concentration if compared to non-diabetic subjects. In conclusion, an immune response to Map in T1DM patients at onset was observed and this may indicate a role of the bacterium in triggering or precipitating the disease.

KeywordsMycobacterium avium subsp paratuberculosis; Type 1 diabetes mellitus; CXCL10; CCL2
PublisherElsevier
JournalCytokine
ISSN1043-4666
Electronic1096-0023
Publication dates
Online21 Dec 2012
Print28 Feb 2013
Publication process dates
Deposited27 Nov 2019
Accepted16 Nov 2012
Output statusPublished
Digital Object Identifier (DOI)https://doi.org/10.1016/j.cyto.2012.11.008
Scopus EID2-s2.0-84873150719
Web of Science identifierWOS:000314742800001
LanguageEnglish
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