MAP3738c and MptD are specific tags of Mycobacterium avium subsp. paratuberculosis infection in type I diabetes mellitus

Article

Cossu, A., Rosu, V., Paccagnini, D., Cossu, D., Pacifico, A. and Sechi, L. 2011. MAP3738c and MptD are specific tags of Mycobacterium avium subsp. paratuberculosis infection in type I diabetes mellitus. Clinical Immunology. 141 (1), pp. 49-57. https://doi.org/10.1016/j.clim.2011.05.002
TypeArticle
TitleMAP3738c and MptD are specific tags of Mycobacterium avium subsp. paratuberculosis infection in type I diabetes mellitus
AuthorsCossu, A., Rosu, V., Paccagnini, D., Cossu, D., Pacifico, A. and Sechi, L.
Abstract

Mycobacterium avium subsp. paratuberculosis (Map) is the causative agent of Johne's disease, a chronic inflammation of ruminants' intestine. Recent studies have linked Map to type I Diabetes mellitus (T1DM). We searched the presence of antibodies against two specific proteins of Map (MptD and MAP3738c) in sera of patients affected by T1DM and type II Diabetes mellitus (T2DM). MptD protein (MAP3733c) has been recognized as a Map virulent factor whereas MAP3738c has not yet been studied. Both proteins are encoded by genes belonging to a Map specific pathogenicity island. Forty three T1DM patients' sera, 56 T2DM patients' sera and 48 healthy subjects' sera were screened by ELISA to evaluate the immunoresponse against MptD or MAP3738c recombinant proteins. Results showed a positive response to both proteins in T1DM patients whereas no difference with controls was found for T2DM patients. Results suggest a potential relation between T1DM and the bacterial infection.

KeywordsMycobacterium avium subsp paratuberculosis; Autoimmune diseases; Type I Diabetes mellitus (T1DM); Recombinant proteins; Seroactivity
PublisherElsevier
JournalClinical Immunology
ISSN1521-6616
Electronic1521-7035
Publication dates
Online14 May 2011
Print31 Oct 2011
Publication process dates
Deposited27 Nov 2019
Accepted05 May 2011
Output statusPublished
Digital Object Identifier (DOI)https://doi.org/10.1016/j.clim.2011.05.002
Scopus EID2-s2.0-80053132667
Web of Science identifierWOS:000295558500006
LanguageEnglish
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