Type 2 diabetes, depressive symptoms and trajectories of cognitive decline in a national sample of community-dwellers: a prospective cohort study

Article

Demakakos, P., Muniz-Terrera, G. and Nouwen, A. 2017. Type 2 diabetes, depressive symptoms and trajectories of cognitive decline in a national sample of community-dwellers: a prospective cohort study. PLoS ONE. 12 (4), pp. 1-14. https://doi.org/10.1371/journal.pone.0175827
TypeArticle
TitleType 2 diabetes, depressive symptoms and trajectories of cognitive decline in a national sample of community-dwellers: a prospective cohort study
AuthorsDemakakos, P., Muniz-Terrera, G. and Nouwen, A.
Abstract

We examined the individual and synergistic effects of type 2 diabetes and elevated depressive symptoms on memory and executive function trajectories over 10 and eight years of follow-up, respectively. Our sample comprised 10,524 community-dwellers aged ≥50 years in 2002±03 from the English Longitudinal Study of Ageing. With respect to memory (word recall), participants with either diabetes or elevated depressive symptoms recalled significantly fewer words compared with those free of these conditions (reference category), but more words compared with those with both conditions. There was a significant acceleration in the rate of memory decline in participants aged ≤50±64 years with both conditions (-0.27, 95% CI, -0.45 to -0.08, per study wave), which was not observed in those with either condition or aged ≥65 years. With respect to executive function (animal naming), participants aged 65 years with diabetes or those with elevated depressive symptoms named significantly fewer animals compared with the reference category, while those with both conditions named fewer animals compared with any other category. The rate of executive function decline was significantly greater in participants with both conditions (-0.54, 95% CI, -0.99 to -0.10; and ±0.71, 95% CI, -1.16 to -0.27, per study wave, for those aged 50±64 and ≥65 years, respectively), but not in participants with either condition. Diabetes and elevated depressive symptoms are inversely associated with memory and executive function, but, individually, do not accelerate cognitive decline. The co-occurrence of diabetes and elevated depressive symptoms significantly accelerates cognitive decline over time, especially among those aged 50±64 years.

Research GroupApplied Health Psychology group
PublisherPublic Library of Science
JournalPLoS ONE
ISSN1932-6203
Publication dates
Print17 Apr 2017
Publication process dates
Deposited28 Apr 2017
Submitted01 Nov 2016
Accepted01 Apr 2017
Output statusPublished
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Copyright Statement

Copyright: © 2017 Demakakos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Digital Object Identifier (DOI)https://doi.org/10.1371/journal.pone.0175827
LanguageEnglish
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Demakakos, Muniz-Terrera, Nouwen (2017) Type 2 diabetes, depressive symptoms and trajectories of cognitive decline in a national sample of community-dwellers- A prospective cohort study.pdf
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