An overview of angiogenesis in bladder cancer

Article


Elayat, G., Punev, I. and Selim, A. 2023. An overview of angiogenesis in bladder cancer. Current Oncology Reports. 25 (7), pp. 709-728. https://doi.org/10.1007/s11912-023-01421-5
TypeArticle
TitleAn overview of angiogenesis in bladder cancer
AuthorsElayat, G., Punev, I. and Selim, A.
Abstract

Purpose of the review: Angiogenesis plays a key role in bladder cancer (BC) pathogenesis. In the last two decades, increasing number of publications depicting a multitude of novel angiogenic molecules and pathways have emerged. The growing complexity necessitates evaluation of the breadth of current knowledge to highlight key findings and guide future research.
Recent findings: Angiogenesis is a dynamic biologic process that is inherently difficult to assess. Clinical assessment of angiogenesis in BCs is advancing with the integration of image analysis systems and dynamic contrast-enhanced and magnetic resonance imaging (DCE-MRI). Tumour associated macrophages (TAMs) significantly influence the angiogenic process and further research is needed to assess their potential as therapeutic targets. A rapidly growing list of non-coding RNAs affect angiogenesis in BCs, partly through modulation of vascular endothelial growth factor (VEGF) activity. Vascular mimicry (VM) has been repeatedly associated with increased tumour aggressiveness in BCs. Standardised assays are needed for appropriate identification and quantification of VM channels.
Summary: This article demonstrates the dynamic and complex nature of the angiogenic process and asserts the need for further studies to deepen our understanding.

Sustainable Development Goals3 Good health and well-being
Middlesex University ThemeHealth & Wellbeing
Research GroupBiomarkers for Cancer group
LanguageEnglish
PublisherSpringer
JournalCurrent Oncology Reports
ISSN1523-3790
Electronic1534-6269
Publication dates
Online13 Apr 2023
PrintJul 2023
Publication process dates
Deposited06 Apr 2023
Accepted28 Mar 2023
Output statusPublished
Publisher's version
License
Accepted author manuscript
File Access Level
Restricted
Digital Object Identifier (DOI)https://doi.org/10.1007/s11912-023-01421-5
Web of Science identifierMEDLINE:37052868
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