Cyclin D-1 protein over-expression is not associated with gene amplification in benign and atypical apocrine lesions of the breast

Article


Elayat, Ghada, Selim, Abdel-Ghani A., Gorman, Patricia, Tomlinson, Ian and Wells, Clive A. 2011. Cyclin D-1 protein over-expression is not associated with gene amplification in benign and atypical apocrine lesions of the breast. Pathology - Research and Practice. 207 (2), pp. 75-78. https://doi.org/10.1016/j.prp.2010.06.003
TypeArticle
TitleCyclin D-1 protein over-expression is not associated with gene amplification in benign and atypical apocrine lesions of the breast
AuthorsElayat, Ghada, Selim, Abdel-Ghani A., Gorman, Patricia, Tomlinson, Ian and Wells, Clive A.
Abstract

Cyclin D-1 protein over-expression and/or gene amplification have been shown to be frequent events in subsets of breast carcinomas. Cyclin D-1 is generally considered as a weak oncogene, and its over-expression has been shown to occur in occasional benign breast lesions. In a previous series, we have shown that cyclin D-1 was over-expressed in subsets of apocrine metaplasia (APM) and apocrine adenosis (AA) of the breast and that such over-expression was mostly associated with a significant increase in the proliferative capacity of these lesions. We examined the mechanisms involved in cyclin D-1 over-expression in apocrine lesions.

A total of 41 cases were analysed in this study. The cases were divided into: 18 cases of APM and 23 cases of AA. All cases analysed had been previously analysed by immunohistochemistry, and all showed over-expression of the cyclin D-1 protein. Fluorescence in situ hybridisation (FISH) was performed using a dual cyclin D-1 (spectrum orange)/chromosome 11 centromere (spectrum green) DNA probe. The results showed that none of the cases studied had concomitant gene amplification.

These results suggest that other post-transcriptional mechanisms might be responsible for cyclin D-1 protein over-expression in benign apocrine lesions. Further studies are needed to understand the mechanisms involved in abnormal cyclin D-1 expression in these lesions.

KeywordsBreast; Apocrine; Metaplasia; Adenosis; FISH
PublisherElsevier
Journal Pathology - Research and Practice
ISSN0344-0338
Publication dates
Online15 Dec 2010
Print15 Feb 2011
Publication process dates
Accepted09 Jun 2010
Deposited26 Sep 2023
Output statusPublished
Digital Object Identifier (DOI)https://doi.org/10.1016/j.prp.2010.06.003
Web of Science identifierWOS:000289011900001
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