Cyclin D-1 protein over-expression is not associated with gene amplification in benign and atypical apocrine lesions of the breast
Article
Elayat, Ghada, Selim, Abdel-Ghani A., Gorman, Patricia, Tomlinson, Ian and Wells, Clive A. 2011. Cyclin D-1 protein over-expression is not associated with gene amplification in benign and atypical apocrine lesions of the breast. Pathology - Research and Practice. 207 (2), pp. 75-78. https://doi.org/10.1016/j.prp.2010.06.003
Type | Article |
---|---|
Title | Cyclin D-1 protein over-expression is not associated with gene amplification in benign and atypical apocrine lesions of the breast |
Authors | Elayat, Ghada, Selim, Abdel-Ghani A., Gorman, Patricia, Tomlinson, Ian and Wells, Clive A. |
Abstract | Cyclin D-1 protein over-expression and/or gene amplification have been shown to be frequent events in subsets of breast carcinomas. Cyclin D-1 is generally considered as a weak oncogene, and its over-expression has been shown to occur in occasional benign breast lesions. In a previous series, we have shown that cyclin D-1 was over-expressed in subsets of apocrine metaplasia (APM) and apocrine adenosis (AA) of the breast and that such over-expression was mostly associated with a significant increase in the proliferative capacity of these lesions. We examined the mechanisms involved in cyclin D-1 over-expression in apocrine lesions. A total of 41 cases were analysed in this study. The cases were divided into: 18 cases of APM and 23 cases of AA. All cases analysed had been previously analysed by immunohistochemistry, and all showed over-expression of the cyclin D-1 protein. Fluorescence in situ hybridisation (FISH) was performed using a dual cyclin D-1 (spectrum orange)/chromosome 11 centromere (spectrum green) DNA probe. The results showed that none of the cases studied had concomitant gene amplification. These results suggest that other post-transcriptional mechanisms might be responsible for cyclin D-1 protein over-expression in benign apocrine lesions. Further studies are needed to understand the mechanisms involved in abnormal cyclin D-1 expression in these lesions. |
Keywords | Breast; Apocrine; Metaplasia; Adenosis; FISH |
Publisher | Elsevier |
Journal | Pathology - Research and Practice |
ISSN | 0344-0338 |
Publication dates | |
Online | 15 Dec 2010 |
15 Feb 2011 | |
Publication process dates | |
Accepted | 09 Jun 2010 |
Deposited | 26 Sep 2023 |
Output status | Published |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.prp.2010.06.003 |
Web of Science identifier | WOS:000289011900001 |
https://repository.mdx.ac.uk/item/8zv2w
49
total views0
total downloads4
views this month0
downloads this month
Export as
Related outputs
Phenotypic plasticity in melanoma: the impact on management strategies
Elayat, G. 2024. Phenotypic plasticity in melanoma: the impact on management strategies. Redactive Publishing.![](/~18/aqs/default-thumbnail.png)