Biomimetic surface functionalization of clinically relevant metals used as orthopaedic and dental implants

Article


García-Gareta, E., Hua, J., Orera, A., Kohli, N., Knowles, J. and Blunn, G. 2017. Biomimetic surface functionalization of clinically relevant metals used as orthopaedic and dental implants. Biomedical Materials. 13 (1). https://doi.org/10.1088/1748-605X/aa87e6
TypeArticle
TitleBiomimetic surface functionalization of clinically relevant metals used as orthopaedic and dental implants
AuthorsGarcía-Gareta, E., Hua, J., Orera, A., Kohli, N., Knowles, J. and Blunn, G.
Abstract

Titanium and its alloys or tantalum (Ta) are materials used in orthopaedic and dental implants due to their excellent mechanical properties and biocompatibility. However, their bioactivity and osteoconductivity is low. With a view to improving the bioactivity of these materials we hypothesised that the surface of Ta and TiAl6V4 can be functionalised with biomimetic, amorphous nano-sized calcium phosphate (CaP) apatite-like deposits, instead of creating uniform coatings, which can lead to flaking, delamination and poor adherence. We used Ta and TiAl6V4 metal discs with smooth and rough surfaces. Amorphous CaP apatite-like particles were deposited on the different surfaces by a biomimetic rapid two-step soaking method using concentrated simulated body fluid (SBF) solutions without a pre-treatment of the metal surfaces to induce CaP deposition. Immersion times in the second SBF solution of 48 and 18 h for Ta and TiAl6V4 respectively produced CaP deposits composed of amorphous globular nano-sized particles that also contained Mg, C and O. Longer immersion times produced more uniform coatings as well as an undesired calcite mineral phase. Prediction of in vivo behaviour by immersion in regular SBF showed that the obtained CaP deposits would act as a catalyst to rapidly form a Ca deficient CaP layer that also incorporates Mg. The amorphous CaP apatite-like deposits promoted initial attachment, proliferation and osteogenic differentiation of bone marrow derived mesenchymal stem cells. Finally, we used our method to functionalise 3D porous structures of titanium alloy made by selective laser sintering. Our study uses a novel and cost-effective approach to functionalise clinically relevant metal surfaces in order to increase the bioactivity of these materials, which could improve their clinical performance.

Research GroupBiophysics and Bioengineering group
LanguageEnglish
PublisherIOP Publishing
JournalBiomedical Materials
ISSN1748-6041
Electronic1748-605X
Publication dates
Online22 Nov 2017
Print22 Nov 2017
Publication process dates
Deposited11 Apr 2018
Accepted23 Aug 2017
Output statusPublished
Accepted author manuscript
Copyright Statement

This is an author-created, un-copyedited version of an article accepted for publication/published in Biomedical Materials. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1748-605X/aa87e6

Digital Object Identifier (DOI)https://doi.org/10.1088/1748-605X/aa87e6
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