A conceptual object modelling of gene mutation data.

Book chapter

Rahman, S. and Khan, N. 2001. A conceptual object modelling of gene mutation data. in: Wingender, E. (ed.) Computer science and biology: proceedings of the German conference on bioinformatics. Braunschweig German Research Center for Biotechnology.. pp. 187-190
Chapter titleA conceptual object modelling of gene mutation data.
AuthorsRahman, S. and Khan, N.
Abstract

For a biomedical and drug development related research, it is essential to analyse the complete data set of human gene mutation data to understand the underlying molecular mechanism of diseases. The gene mutation database [Cooper et al. 1998] represents a rich source of information and it contains a huge number of entries. However, it lacks the complete data sets which is essential to analyse the trait for indirect association of diseases. A typical example in this context would be to analyse the Recombination Fraction () and Relative Dinucleotide Mutabilities (rdm) [Cooper and Krawczak, 1993].
Paton et al. (2000) developed a conceptual model for genomic and related functional data sets, but they used genome data warehouses to implement the model. However, it is evident that data warehouses produce data redundancy and attribute overlapping. Here the paper proposes the theoretical concept for an object model of gene mutation data. The initial outline of this conceptual model interpreting an integrated co-operative framework had been proposed in another paper [Khan et al., 2001].

Page range187-190
Book titleComputer science and biology: proceedings of the German conference on bioinformatics.
EditorsWingender, E.
PublisherGerman Research Center for Biotechnology.
Place of publicationBraunschweig
ISBN
Hardcover3000081143
Publication process dates
Deposited08 Apr 2009
Output statusPublished
Additional information

Conference held on October 7 - 10, 2001, Braunschweig.

Web address (URL)http://www.bioinfo.de/isb/gcb01/poster/index.html
LanguageEnglish
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