Aggression following traumatic brain injury: effectiveness of Risperidone (AFTER): study protocol for a feasibility randomised controlled trial
Article
Deb, S., Leeson, V., Aimola, L., Bodani, M., Li, L., Weaver, T., Sharp, D. and Crawford, M. 2018. Aggression following traumatic brain injury: effectiveness of Risperidone (AFTER): study protocol for a feasibility randomised controlled trial. Trials. 19. https://doi.org/10.1186/s13063-018-2601-z
Type | Article |
---|---|
Title | Aggression following traumatic brain injury: effectiveness of Risperidone (AFTER): study protocol for a feasibility randomised controlled trial |
Authors | Deb, S., Leeson, V., Aimola, L., Bodani, M., Li, L., Weaver, T., Sharp, D. and Crawford, M. |
Abstract | Background: Traumatic brain injury (TBI) is a major public health concern and many people develop long-lasting physical and neuropsychiatric consequences following a TBI. Despite the emphasis on physical rehabilitation, it is the emotional and behavioural consequences that have greater impact on people with TBI and their families. One such problem behaviour is aggression which can be directed towards others, towards property or towards the self.Aggression is reported to be common after TBI (37–71%) and causes major stress for patients and their families.Both drug and non-drug interventions are used to manage this challenging behaviour, but the evidence-base for these interventions is poor and no drugs are currently licensed for the treatment of aggression following TBI. The most commonly used drugs for this purpose are antipsychotics, particularly second-generation drugs such as risperidone. Despite this widespread use, randomised controlled trials (RCTs) of antipsychotic drugs, including risperidone, have not been conducted. We have, therefore, set out to test the feasibility of conducting an RCT of this drug for people who have aggressive behaviour following TBI. |
Keywords | Traumatic brain injury ; Aggression; Pharmacological intervention; Risperidone; Feasibility; RCT |
Publisher | BioMed Central |
Journal | Trials |
ISSN | 1745-6215 |
Publication dates | |
Online | 21 Jun 2018 |
01 Dec 2018 | |
Publication process dates | |
Deposited | 03 Jan 2019 |
Accepted | 19 Mar 2018 |
Output status | Published |
Publisher's version | License File Access Level Open |
Copyright Statement | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 |
Digital Object Identifier (DOI) | https://doi.org/10.1186/s13063-018-2601-z |
PubMed ID | 29929537 |
PubMed Central ID | 6013952 |
Web of Science identifier | WOS:000435865800001 |
Related Output | |
Has version | http://europepmc.org/abstract/med/29929537 |
Language | English |
https://repository.mdx.ac.uk/item/88173
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