Biomarkers for Cancer group
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Latest research outputs
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Raised circulating levels of interleukin-6 in women with an intrauterine contraceptive device.
Wolley, J., Saleem, S., Hills, F., Salem, H., El-Nashar, E. and Chard, T. 1996. Raised circulating levels of interleukin-6 in women with an intrauterine contraceptive device. Gynecologic and Obstetric Investigation. 42 (4), pp. 241-243.Article
Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: relation to birthweight and maternal weight.
Hills, F., English, J. and Chard, T. 1996. Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: relation to birthweight and maternal weight. Journal of Endocrinology. 148 (2), pp. 303-309. https://doi.org/10.1677/joe.0.1480303Article
Antenatal dexamethasone therapy does not affect circulating concentrations of insulin-like growth factor binding protein-1.
Ogueh, O., Hills, F., Chard, T. and Johnson, M. 1998. Antenatal dexamethasone therapy does not affect circulating concentrations of insulin-like growth factor binding protein-1. Human Reproduction. 13 (6), pp. 1714-1716. https://doi.org/10.1093/humrep/13.6.1714Article
Effects of co-trimoxazole, erythromycin, amoxycillin, tetracycline and chloroquine on sperm function in vitro
Hargreaves, C., Rogers, S., Hills, F., Rahman, F., Howell, R. and Homa, S. 1998. Effects of co-trimoxazole, erythromycin, amoxycillin, tetracycline and chloroquine on sperm function in vitro. Human Reproduction. 13 (7), pp. 1878-1886.Article
Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression
Monk, D., Arnaud, P., Frost, J., Hills, F., Stanier, P., Feil, R. and Moore, G. 2009. Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression. Human Molecular Genetics. 18 (16), pp. 3066-3074. https://doi.org/10.1093/hmg/ddp248Article
A human domain antibody and Lewisb glycoconjugate that inhibit binding of helicobacter pylori to Lewisb receptor and adhesion to human gastric epithelium
Younson, J., O'Mahony, R., Liu, H., Grant, S., Campion, C., Jennings, L., Vaira, D., Kelly, C., Roitt, I. and Holton, J. 2009. A human domain antibody and Lewisb glycoconjugate that inhibit binding of helicobacter pylori to Lewisb receptor and adhesion to human gastric epithelium. Journal of Infectious Diseases. 200 (10), pp. 1574-1582. https://doi.org/10.1086/644596Article
Designing a new generation of anti-hCG vaccines for cancer therapy
Delves, P., Iles, R., Roitt, I. and Lund, T. 2007. Designing a new generation of anti-hCG vaccines for cancer therapy. Molecular and Cellular Endocrinology. 260-26, pp. 276-281. https://doi.org/10.1016/j.mce.2006.02.018Article
Refocusing of B-cell responses following a single amino acid substitution in an antigen.
Dalla Chiesa, M., Martensen, P., Simmons, C., Porakishvili, N., Justesen, J., Dougan, G., Roitt, I., Delves, P. and Lund, T. 2001. Refocusing of B-cell responses following a single amino acid substitution in an antigen. Immunology. 103 (2), pp. 172-178. https://doi.org/10.1046/j.1365-2567.2001.01242.xArticle
Tumour burden and Interleukin-2 (IL-2) dose affect the interaction between low-dose total body irradiation and Interleukin-2.
Safwat, A., Aggerholm, N., Roitt, I., Overgaard, J. and Hoklund, M. 2004. Tumour burden and Interleukin-2 (IL-2) dose affect the interaction between low-dose total body irradiation and Interleukin-2. European Journal of Cancer. 40 (9), pp. 1412-1417. https://doi.org/10.1016/j.ejca.2004.01.037Article
Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells.
Kvirkvelia, N., Vojnovic, I., Warner, T., Athie-Morales, V., Free, P., Rayment, N., Chain, B., Rademacher, T., Lund, T., Roitt, I. and Delves, P. 2002. Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells. Clinical & Experimental Immunology. 127 (2), pp. 263-269. https://doi.org/10.1046/j.1365-2249.2002.01718.xArticle
Low dose total body irradiation augments the therapeutic effect of interleukin-2 in a mouse model for metastatic malignant melanoma.
Safwat, A., Aggerholm, N., Roitt, I., Overgaard, J. and Hoklund, M. 2003. Low dose total body irradiation augments the therapeutic effect of interleukin-2 in a mouse model for metastatic malignant melanoma. Journal of experimental therapeutics & oncology. 3 (4), pp. 161-168. https://doi.org/10.1046/j.1359-4117.2003.01093.xArticle
Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis.
De Bernardis, F., Liu, H., O'Mahony, R., La Valle, R., Bartollino, S., Sandini, S., Grant, S., Brewis, N., Tomlinson, I., Basset, R., Holton, J., Roitt, I. and Cassone, A. 2007. Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis. Journal of Infectious Diseases. 195 (1), pp. 149-157. https://doi.org/10.1086/509891Article
Comparison of image analysis software packages in the assessment of adhesion of microorganisms to mucosal epithelium using confocal laser scanning microscopy.
O'Mahony, R., Basset, C., Holton, J., Vaira, D. and Roitt, I. 2005. Comparison of image analysis software packages in the assessment of adhesion of microorganisms to mucosal epithelium using confocal laser scanning microscopy. Elsevier. https://doi.org/10.1016/j.mimet.2004.11.020Conference paper
Changes in the reproductive system of male mice immunized with a GnRH-analogue conjugated to mycobacterial hsp70
Hannesdottir, S., Han, X., Lund, T., Singh, M., Van Der Zee, R., Roitt, I. and Delves, P. 2004. Changes in the reproductive system of male mice immunized with a GnRH-analogue conjugated to mycobacterial hsp70. Reproduction: the official journal of the Society for the Study of Fertility. 128 (3), pp. 365-371. https://doi.org/10.1530/rep.1.00108Article
Innate immunity and pathogen-host interaction.
Basset, C., Holton, J., O'Mahony, R. and Roitt, I. 2003. Innate immunity and pathogen-host interaction. Vaccine. 21 (Supple), pp. S12-S23. https://doi.org/10.1016/S0264-410X(03)00195-6Article
Elimination of luteinizing hormone cross-reactive epitopes from human chorionic gonadotropin.
Porakishvili, N., Chiesa, M., Chikadze, N., Martensen, P., Justesen, J., Lund, T., Delves, P. and Roitt, I. 2002. Elimination of luteinizing hormone cross-reactive epitopes from human chorionic gonadotropin. Vaccine. 20 (16), pp. 2053-2059. https://doi.org/10.1016/S0264-410X(02)00051-8Article
Genes and IgG glycosylation in autoimmune and non-autoimmune strains of mice
Delves, P., Lund, T. and Roitt, I. 2002. Genes and IgG glycosylation in autoimmune and non-autoimmune strains of mice. Trends in Immunology. 23 (4), pp. 213-219. https://doi.org/10.1016/S1471-4906(02)02182-8Article
The human chorionic gonadotropin-ß arginine68 to glutamic acid substitution fixes the conformation of the C-terminal Peptide
Charrel-Dennis, M., Terrazzini, N., McBride, J., Martensen, P., Justesen, J., Berger, P., Lapthorn, A., Kelly, C., Roitt, I., Delves, P. and Lund, T. 2005. The human chorionic gonadotropin-ß arginine68 to glutamic acid substitution fixes the conformation of the C-terminal Peptide. Molecular Endocrinology. 19 (7), pp. 1803-1811. https://doi.org/10.1210/me.2004-0109Article
The major hormone-specific epitopes on human chorionic gonadotropin
Charrel-Dennis, M., Jackson, A., Lund, T., Lapthorn, A., Berger, P., Roitt, I. and Delves, P. 2004. The major hormone-specific epitopes on human chorionic gonadotropin. Journal of molecular endocrinology. 32 (2), pp. 571-581.Article
Immunochemical mapping of gonadotropin
Berger, P., Bidart, J., Delves, P., Dirnhofer, S., Hoermann, R., Isaacs, N., Jackson, A., Klonisch, T., Lapthorn, A., Lund, T., Mann, K., Roitt, I., Schwartz, S. and Wick, G. 1996. Immunochemical mapping of gonadotropin. Molecular and Cellular Endocrinology. 125 (1-2), pp. 33-43. https://doi.org/10.1016/S0303-7207(96)03943-3Article
Rod outer segment membrane guanylate cyclase type 1 (ROS-GC1) calcium-modulated transduction system in the sperm
Jankowska, A., Burczynska, B., Duda, T. and Warchol, J. 2010. Rod outer segment membrane guanylate cyclase type 1 (ROS-GC1) calcium-modulated transduction system in the sperm. Fertility and Sterility. 93 (3), pp. 904-912. https://doi.org/10.1016/j.fertnstert.2008.10.048Article
Estradiol, progesterone, testosterone profiles in human follicular fluid and cultured granulosa cells from luteinized pre-ovulatory follicles
Wen, S., Li, D., Tozer, A., Docherty, S. and Iles, R. 2010. Estradiol, progesterone, testosterone profiles in human follicular fluid and cultured granulosa cells from luteinized pre-ovulatory follicles. Reproductive Biology and Endocrinology. 8 (117). https://doi.org/10.1186/1477-7827-8-117Article
High follicular fluid adenosine levels may be pivotal in the metabolism and recycling of adenosine nucleotides in the human follicle
Wen, S., Perrett, D., Jones, N., Tozer, A., Docherty, S. and Iles, R. 2010. High follicular fluid adenosine levels may be pivotal in the metabolism and recycling of adenosine nucleotides in the human follicle. Metabolism: Clinical and Experimental. 59 (8), pp. 1145-1155. https://doi.org/10.1016/j.metabol.2009.09.037Article
Capillary electrophoresis of human follicular fluid
Wen, S., Perrett, D., Patel, P., Li, N., Docherty, S., Tozer, A. and Iles, R. 2009. Capillary electrophoresis of human follicular fluid. Journal of Chromatography B. 877 (31), pp. 3946-3952. https://doi.org/10.1016/j.jchromb.2009.09.046Article
Heparin prevents programmed cell death in human trophoblast
Hills, F., Abrahams, V., Gonzalez-Timon, B., Francis, J., Cloke, B., Hinkson, L., Rai, R., Regan, L., Mor, G., Sullivan, M., Lam, E. and Brosens, J. 2006. Heparin prevents programmed cell death in human trophoblast. Molecular Human Reproduction. 12 (4), pp. 237-242.Article
Laser modulation of angiogenic factor production by T-lymphocytes.
Agaiby, A., Ghali, L., Wilson, R. and Dyson, M. 2000. Laser modulation of angiogenic factor production by T-lymphocytes. Lasers in surgery and medicine. 26 (4), pp. 357-363. https://doi.org/10.1002/(SICI)1096-9101(2000)26:4<357::AID-LSM3>3.0.CO;2-OArticle
An association between sebaceous carcinoma and microsatellite instability in immunosuppressed organ transplant recipients
Harwood, C., Swale, V., Bataille, V., Quinn, A., Ghali, L., Patel, S., Dove-Edwin, I., Cerio, R. and McGregor, J. 2001. An association between sebaceous carcinoma and microsatellite instability in immunosuppressed organ transplant recipients. Journal of investigative dermatology. 116 (2), pp. 246-253. https://doi.org/10.1046/j.1523-1747.2001.01233.xArticle
Human β defensin-1 and -2 expression in human pilosebaceous units: upregulation in acne vulgaris lesions
Chronnell, C., Ghali, L., Ali, R., Quinn, A., Holland, D., Bull, J., Cunliffe, W., McKay, I., Philpott, M. and Müller-Röver, S. 2001. Human β defensin-1 and -2 expression in human pilosebaceous units: upregulation in acne vulgaris lesions. Journal of investigative dermatology. 117 (5), pp. 1120-1125. https://doi.org/10.1046/j.0022-202x.2001.01569.xArticle
Reduced apoptotic levels in squamous but not basal cell carcinomas correlates with detection of cutaneous human papillomavirus
Jackson, S., Ghali, L., Harwood, C. and Storey, A. 2002. Reduced apoptotic levels in squamous but not basal cell carcinomas correlates with detection of cutaneous human papillomavirus. British journal of cancer. 87 (3), pp. 319-323. https://doi.org/10.1038/sj.bjc.6600431Article
Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization
Bloor, B., Tidman, N., Leigh, I., Odell, E., Dogan, B., Wollina, U., Ghali, L. and Waseem, A. 2003. Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization. American Journal of Pathology. 162 (3), pp. 963-975.Article
The E7 protein of cutaneous human papillomavirus type 8 causes invasion of human keratinocytes into the dermis in organotypic cultures of skin
Akgul, B., Garcia-Escudero, R., Ghali, L., Pfister, H., Fuchs, P., Navsaria, H. and Storey, A. 2005. The E7 protein of cutaneous human papillomavirus type 8 causes invasion of human keratinocytes into the dermis in organotypic cultures of skin. Cancer Research. 65 (6), pp. 2216-2223. https://doi.org/10.1158/0008-5472.CAN-04-1952Article
LEKTI demonstrable by immunohistochemistry of the skin: a potential diagnostic skin test for Netherton syndrome.
Ong, C., O'Toole, E., Ghali, L., Malone, M., Smith, V., Callard, R. and Harper, J. 2004. LEKTI demonstrable by immunohistochemistry of the skin: a potential diagnostic skin test for Netherton syndrome. British journal of dermatology. 151 (6), pp. 1253-1257. https://doi.org/10.1111/j.1365-2133.2004.06180.xArticle
Safety and efficacy of 5% imiquimod cream for the treatment of skin dysplasia in high-risk renal transplant recipients: randomized, double-blind, placebo-controlled trial
Brown, V., Atkins, C., Ghali, L., Cerio, R., Harwood, C. and Proby, C. 2005. Safety and efficacy of 5% imiquimod cream for the treatment of skin dysplasia in high-risk renal transplant recipients: randomized, double-blind, placebo-controlled trial. Archives of Dermatology. 141 (8), pp. 985-993.Article
Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours
Green, J., Ikram, M., Vyas, J., Patel, N., Proby, C., Ghali, L., Leigh, I., O'Toole, E. and Storey, A. 2006. Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours. British journal of cancer. 94 (10), pp. 1446-1451.Article
Role of HPV E6 proteins in preventing UVB-induced release of pro-apoptotic factors from the mitochondria.
Leverrier, S., Bergamaschi, D., Ghali, L., Ola, A., Warnes, G., Akgul, B., Blight, K., Garcia-Escudero, R., Penna, A., Eddaoudi, A. and Storey, A. 2007. Role of HPV E6 proteins in preventing UVB-induced release of pro-apoptotic factors from the mitochondria. Apoptosis: an international journal on programmed cell death. 12 (3), pp. 549-560. https://doi.org/10.1007/s10495-006-0004-1Article
Role for WNT16B in human epidermal keratinocyte proliferation and differentiation
Teh, M., Blaydon, D., Ghali, L., Briggs, V., Edmunds, S., Pantazi, E., Barnes, M., Leigh, I., Kelsell, D. and Philpott, M. 2007. Role for WNT16B in human epidermal keratinocyte proliferation and differentiation. Journal of Cell Science. 120 (2), pp. 330-339.Article
Longitudinal muscle shows abnormal relaxation responses to nitric oxide and contains altered levels of NOS1 and elastin in uncomplicated diverticular disease.
Golder, M., Burleigh, D., Ghali, L., Feakins, R., Lunniss, P., Williams, N. and Navsaria, H. 2007. Longitudinal muscle shows abnormal relaxation responses to nitric oxide and contains altered levels of NOS1 and elastin in uncomplicated diverticular disease. Colorectal disease. 9 (3), pp. 218-228.Article
HPV8 early genes modulate differentiation and cell cycle of primary human adult keratinocytes.
Akgul, B., Ghali, L., Davies, D., Pfister, H., Leigh, I. and Storey, A. 2007. HPV8 early genes modulate differentiation and cell cycle of primary human adult keratinocytes. Clinical and experimental dermatology. 16 (7), pp. 590-599.Article
Granulosa cell survival and proliferation are altered in polycystic ovary syndrome
Das, M., Djahanbakhch, O., Hacihanefioglu, B., Saridogan, E., Ikram, M., Ghali, L., Raveendran, M. and Storey, A. 2008. Granulosa cell survival and proliferation are altered in polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism. 93 (3), pp. 881-887. https://doi.org/10.1210/jc.2007-1650Article
GLI1 repression of ERK activity correlates with colony formation and impaired migration in human epidermal keratinocytes
Neill, G., Harrison, W., Ikram, M., Williams, T., Bianchi, L., Nadenla, S., Green, J., Ghali, L., Frischauf, A., O'Toole, E., Aberger, F. and Philpott, M. 2008. GLI1 repression of ERK activity correlates with colony formation and impaired migration in human epidermal keratinocytes. Carcinogenesis. 29 (4), pp. 738-746. https://doi.org/10.1093/carcin/bgn037Article
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