Spanos, C.; Maldonado, E.M.; Fisher, C.P.; Leenutaphong, P.; Oviedo-Orta, E.; Windridge, D.; Salguero, F.J.; Bermúdez-Fajardo, A.; Weeks, M.E.; Evans, C.; Corfe, B.M.; Rabbani, N.; Thornalley, P.J.; Miller, M.H.; Wang, H.; Dillon, J.F.; Quaglia, A.; Dhawan, A.; Fitzpatrick, E.; Moore, J.B.

Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease

Article

Spanos, C., Maldonado, E.M., Fisher, C.P., Leenutaphong, P., Oviedo-Orta, E., Windridge, D., Salguero, F.J., Bermúdez-Fajardo, A., Weeks, M.E., Evans, C., Corfe, B.M., Rabbani, N., Thornalley, P.J., Miller, M.H., Wang, H., Dillon, J.F., Quaglia, A., Dhawan, A., Fitzpatrick, E. and Moore, J.B. 2018. Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease. Proteome Science. 16 (1). https://doi.org/10.1186/s12953-018-0131-y

Publication dates
Type	Article
Title	Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease
Authors	Spanos, C., Maldonado, E.M., Fisher, C.P., Leenutaphong, P., Oviedo-Orta, E., Windridge, D., Salguero, F.J., Bermúdez-Fajardo, A., Weeks, M.E., Evans, C., Corfe, B.M., Rabbani, N., Thornalley, P.J., Miller, M.H., Wang, H., Dillon, J.F., Quaglia, A., Dhawan, A., Fitzpatrick, E. and Moore, J.B.
Abstract	Background: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. However, its molecular pathogenesis is incompletely characterized and clinical biomarkers remain scarce. The aims of these experiments were to identify and characterize liver protein alterations in an animal model of early, diet-related, liver injury and to assess novel candidate biomarkers in NAFLD patients. Methods: Liver membrane and cytosolic protein fractions from high fat fed apolipoprotein E knockout (ApoE−/−) animals were analyzed by quantitative proteomics, utilizing isobaric tags for relative and absolute quantitation (iTRAQ) combined with nano-liquid chromatography and tandem mass spectrometry (nLC-MS/MS). Differential protein expression was confirmed independently by immunoblotting and immunohistochemistry in both murine tissue and biopsies from paediatric NAFLD patients. Candidate biomarkers were analyzed by enzyme-linked immunosorbent assay in serum from adult NAFLD patients. Results: Through proteomic profiling, we identified decreased expression of hepatic glyoxalase 1 (GLO1) in a murine model. GLO1 protein expression was also found altered in tissue biopsies from paediatric NAFLD patients. In vitro experiments demonstrated that, in response to lipid loading in hepatocytes, GLO1 is first hyperacetylated then ubiquitinated and degraded, leading to an increase in reactive methylglyoxal. In a cohort of 59 biopsy-confirmed adult NAFLD patients, increased serum levels of the primary methylglyoxal-derived advanced glycation endproduct, hydroimidazolone (MG-H1) were significantly correlated with body mass index (r = 0.520, p < 0.0001). Conclusion: Collectively these results demonstrate the dysregulation of GLO1 in NAFLD and implicate the acetylation-ubquitination degradation pathway as the functional mechanism. Further investigation of the role of GLO1 in the molecular pathogenesis of NAFLD is warranted.
Keywords	Non-alcoholic fatty liver disease; Glyoxalase; Methylglyoxal ; Proteomics; iTRAQ
Publisher	BioMed Central
Journal	Proteome Science
ISSN	1477-5956
Online	14 Feb 2018
Print	14 Feb 2018
Publication process dates
Deposited	27 Feb 2018
Accepted	04 Feb 2018
Submitted	11 Jul 2017
Output status	Published
Publisher's version	s12953-018-0131-y.pdf License CC BY 4.0 File Access Level Open
Supplemental file	s12953-018-0142-8.pdf License CC BY 4.0 File Access Level Open
Copyright Statement	© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Additional information	A Correction to this article was published on 25 June 2018 : https://proteomesci.biomedcentral.com/articles/10.1186/s12953-018-01...
Digital Object Identifier (DOI)	https://doi.org/10.1186/s12953-018-0131-y
PubMed ID	29456458
PubMed Central ID	5813374
Web of Science identifier	WOS:000425756600001
Language	English

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Windridge, D., Kittler, J., De Campos, T., Yan, F., Christmas, W. and Khan, A. 2015. A novel Markov logic rule induction strategy for characterizing sports video footage. IEEE MultiMedia. 22 (2), pp. 24-35. https://doi.org/10.1109/MMUL.2014.36

Artificial co-drivers as a universal enabling technology for future intelligent vehicles and transportation systems

Da Lio, M., Biral, F., Bertolazzi, E., Galvani, M., Bosetti, P., Windridge, D., Saroldi, A. and Tango, F. 2015. Artificial co-drivers as a universal enabling technology for future intelligent vehicles and transportation systems. IEEE Transactions on Intelligent Transportation Systems. 16 (1), pp. 244-263. https://doi.org/10.1109/TITS.2014.2330199

Breast cancer data analytics with missing values: a study on ethnic, age and income groups

Tirunagari, S., Poh, N., Abdulrahman, H., Nemmour, N. and Windridge, D. 2015. Breast cancer data analytics with missing values: a study on ethnic, age and income groups. ArXiv e-prints: Quantitative Biology > Quantitative Methods. https://doi.org/10.48550/arXiv.1503.03680

Detection of face spoofing using visual dynamics

Tirunagari, S., Poh, N., Windridge, D., Iorliam, A., Suki, N. and Ho, A. 2015. Detection of face spoofing using visual dynamics. IEEE Transactions on Information Forensics and Security. 10 (4), pp. 762-777. https://doi.org/10.1109/TIFS.2015.2406533

Multilevel Chinese takeaway process and label-based processes for rule induction in the context of automated sports video annotation

Khan, A., Windridge, D. and Kittler, J. 2014. Multilevel Chinese takeaway process and label-based processes for rule induction in the context of automated sports video annotation. IEEE Transactions on Cybernetics. 44 (10), pp. 1910-1923. https://doi.org/10.1109/TCYB.2014.2299955

Domain anomaly detection in machine perception: a system architecture and taxonomy

Kittler, J., Christmas, W., De Campos, T., Windridge, D., Yan, F., Illingworth, J. and Osman, M. 2014. Domain anomaly detection in machine perception: a system architecture and taxonomy. IEEE Transactions on Pattern Analysis and Machine Intelligence. 36 (5), pp. 845-859. https://doi.org/10.1109/TPAMI.2013.209

A saliency-based framework for 2D-3D registration

Brown, M., Guillemaut, J. and Windridge, D. 2014. A saliency-based framework for 2D-3D registration. 9th International Conference on Computer Vision Theory and Applications (VISAPP 2014). Lisbon, Portugal 05 - 08 Jan 2014 SCITEPRESS - Science and Technology Publications. pp. 265-273 https://doi.org/10.5220/0004675402650273

Supervised selective kernel fusion for membrane protein prediction

Tatarchuk, A., Sulimova, V., Torshin, I., Mottl, V. and Windridge, D. 2014. Supervised selective kernel fusion for membrane protein prediction. Comin, M., Käll, L., Marchiori, E., Ngom, A. and Rajapakse, J. (ed.) 9th IAPR International Conference Pattern Recognition in Bioinformatics (PRIB 2014). Stockholm, Sweden 21 - 23 Aug 2014 Springer. pp. 98-109 https://doi.org/10.1007/978-3-319-09192-1_9

Challenges in designing an online healthcare platform for personalised patient analytics

Poh, N., Tirunagari, S. and Windridge, D. 2014. Challenges in designing an online healthcare platform for personalised patient analytics. 2014 IEEE Symposium on Computational Intelligence in Big Data (CIBD). Orlando, FL., USA 09 - 12 Dec 2014 IEEE. pp. 1-6 https://doi.org/10.1109/CIBD.2014.7011526

Patient level analytics using self-organising maps: a case study on type-1 diabetes self-care survey responses

Tirunagari, S., Poh, N., Aliabadi, K., Windridge, D. and Cooke, D. 2014. Patient level analytics using self-organising maps: a case study on type-1 diabetes self-care survey responses. 2014 IEEE Symposium on Computational Intelligence and Data Mining (CIDM). Orlando, FL., USA 09 - 12 Dec 2014 Institute of Electrical and Electronics Engineers (IEEE). pp. 304-309 https://doi.org/10.1109/CIDM.2014.7008682

Non-enumerative cross validation for the determination of structural parameters in feature-selective SVMs

Chernousova, E., Levdik, P., Tatarchuk, A., Mottl, V. and Windridge, D. 2014. Non-enumerative cross validation for the determination of structural parameters in feature-selective SVMs. 22nd International Conference on Pattern Recognition ICPR 2014. Stockholm, Sweden 24 - 28 Aug 2014 Institute of Electrical and Electronics Engineers (IEEE). pp. 3654-3659 https://doi.org/10.1109/ICPR.2014.628

Linear regression via elastic net: non-enumerative leave-one-out verification of feature selection

Chernousova, E., Razin, N., Krasotkina, O., Mottl, V. and Windridge, D. 2014. Linear regression via elastic net: non-enumerative leave-one-out verification of feature selection. in: Aleskerov, F., Goldengorin, B. and Pardalos, P. (ed.) Clusters, Orders, and Trees: Methods and Applications: In Honor of Boris Mirkin's 70th Birthday New York Springer.

Automatic annotation of tennis games: an integration of audio, vision, and learning

Yan, F., Kittler, J., Windridge, D., Christmas, W., Mikolajczyk, K., Cox, S. and Huang, Q. 2014. Automatic annotation of tennis games: an integration of audio, vision, and learning. Image and Vision Computing. 32 (11), pp. 896-903. https://doi.org/10.1016/j.imavis.2014.08.004

A kernel-based framework for medical big-data analytics

Windridge, D. and Bober, M. 2014. A kernel-based framework for medical big-data analytics. in: Interactive Knowledge Discovery and Data Mining in Biomedical Informatics: State-of-the-Art and Future Challenges Springer. pp. 197-208

Trained eyes: experience promotes adaptive gaze control in dynamic and uncertain visual environments

Taya, S., Windridge, D. and Osman, M. 2013. Trained eyes: experience promotes adaptive gaze control in dynamic and uncertain visual environments. PLoS ONE. 8 (8). https://doi.org/10.1371/journal.pone.0071371

High throughput screening for mammography using a human-computer interface with rapid serial visual presentation (RSVP)

Abbey, C., Hope, C., Sterr, A., Elangovan, P., Geades, N., Windridge, D., Young, K., Wells, K. and Mello-Thoms, C. 2013. High throughput screening for mammography using a human-computer interface with rapid serial visual presentation (RSVP). SPIE Proceedings Vol. 8673. https://doi.org/10.1117/12.2007557

Looking to score: the dissociation of goal influence on eye movement and meta-attentional allocation in a complex dynamic natural scene

Taya, S., Windridge, D. and Osman, M. 2012. Looking to score: the dissociation of goal influence on eye movement and meta-attentional allocation in a complex dynamic natural scene. PLoS ONE. 7 (6). https://doi.org/10.1371/journal.pone.0039060

Automatic annotation of court games with structured output learning

Yan, F., Kittler, J., Mikolajczyk, K. and Windridge, D. 2012. Automatic annotation of court games with structured output learning. 21st International Conference on Pattern Recognition. Tsukuba, Japan 11 - 15 Nov 2012 IEEE. pp. 3577-3580 https://doi.org/https://ieeexplore.ieee.org/document/6460938

Application of the multi-modal relevance vector machine to the problem of protein secondary structure prediction

Razin, N., Sungurov, D., Mottl, V., Torshin, I., Sulimova, V., Seredin, O. and Windridge, D. 2012. Application of the multi-modal relevance vector machine to the problem of protein secondary structure prediction. 7th IAPR International Conference on Pattern Recognition in Bioinformatics. Tokyo, Japan 08 - 10 Nov 2012 Springer. pp. 153-165 https://doi.org/10.1007/978-3-642-34123-6_14

Anomaly detection and knowledge transfer in automatic sports video annotation

Almajai, I., Yan, F., De Campos, T., Khan, A., Christmas, W., Windridge, D. and Kittler, J. 2011. Anomaly detection and knowledge transfer in automatic sports video annotation. in: Weinshall, D., Anemüller, J. and Gool, L. (ed.) Detection and Identification of Rare Audio-visual Cues Springer. pp. 109-117

An evaluation of bags-of-words and spatio-temporal shapes for action recognition

de Campos, T., Barnard, M., Mikolajczyk, K., Kittler, J., Yan, F., Christmas, W. and Windridge, D. 2011. An evaluation of bags-of-words and spatio-temporal shapes for action recognition. 2011 IEEE Workshop on Applications of Computer Vision (WACV). Kona, HI, USA 05 - 07 Jan 2011 IEEE. https://doi.org/10.1109/WACV.2011.5711524

A modified neutral point method for kernel-based fusion of pattern-recognition modalities with incomplete data sets

Panov, M., Tatarchuk, A., Mottl, V. and Windridge, D. 2011. A modified neutral point method for kernel-based fusion of pattern-recognition modalities with incomplete data sets. 10th International Workshop on Multiple Classifier Systems. Naples, Italy 15 - 17 Jun 2011 Springer. https://doi.org/10.1007/978-3-642-21557-5_15

Ball event recognition using HMM for automatic tennis annotation

Almajai, I., Kittler, J., De Campos, T., Christmas, W., Yan, F., Windridge, D. and Khan, A. 2010. Ball event recognition using HMM for automatic tennis annotation. 2010 IEEE International Conference on Image Processing. Hong Kong, China 26 - 29 Sep 2010 IEEE. https://doi.org/10.1109/ICIP.2010.5652415

Adaptive, perception-action-based cognitive modelling of human driving behaviour using control, gaze and signal inputs

Shaukat, A., Windridge, D., Hollnagel, E., Macchi, L. and Kittler, J. 2010. Adaptive, perception-action-based cognitive modelling of human driving behaviour using control, gaze and signal inputs. Brain Inspired Cognitive Systems - BICS 2010. Madrid, Spain 14 - 16 Jul 2010

A support kernel machine for supervised selective combining of diverse pattern-recognition modalities

Tatarchuk, A., Urlov, E., Mottl, V. and Windridge, D. 2010. A support kernel machine for supervised selective combining of diverse pattern-recognition modalities. 9th International Workshop on Multiple Classifier Systems. Cairo, Egypt 07 - 09 Apr 2010 Springer. https://doi.org/10.1007/978-3-642-12127-2_17

Addressing missing values in kernel-based multimodal biometric fusion using neutral point substitution

Poh, N., Windridge, D., Mottl, V., Tatarchuk, A. and Eliseyev, A. 2010. Addressing missing values in kernel-based multimodal biometric fusion using neutral point substitution. IEEE Transactions on Information Forensics and Security. 5 (3), pp. 461-469. https://doi.org/10.1109/TIFS.2010.2053535

A linear-complexity reparameterisation strategy for the hierarchical bootstrapping of capabilities within perception-action architectures

Shevchenko, M., Windridge, D. and Kittler, J. 2009. A linear-complexity reparameterisation strategy for the hierarchical bootstrapping of capabilities within perception-action architectures. Image and Vision Computing. 27 (11), pp. 1702-1714. https://doi.org/10.1016/j.imavis.2008.12.002

An entropy-based approach to the hierarchical acquisition of perception-action capabilities

Windridge, D., Shevchenko, M. and Kittler, J. 2008. An entropy-based approach to the hierarchical acquisition of perception-action capabilities. 4th International Workshop on Cognitive Vision. Santorini, Greece 12 May 2008 Springer. https://doi.org/10.1007/978-3-540-92781-5_7

A memory architecture and contextual reasoning framework for cognitive vision

Kittler, J., Christmas, W.J., Kostin, A., Yan, F., Kolonias, I. and Windridge, D. 2005. A memory architecture and contextual reasoning framework for cognitive vision. 14th Scandinavian Conference on Image Analysis. Joensuu, Finland 19 - 22 Jun 2005 Springer. https://doi.org/10.1007/11499145_36

A linguistic feature vector for the visual interpretation of sign language

Bowden, R., Windridge, D., Kadir, T., Zisserman, A. and Brady, M. 2004. A linguistic feature vector for the visual interpretation of sign language. 8th European Conference on Computer Vision. Prague, Czech Republic 11 - 14 May 2004 Springer. https://doi.org/10.1007/978-3-540-24670-1_30

A general strategy for hidden markov chain parameterisation in composite feature-spaces

Windridge, D., Bowden, R. and Kittler, J. 2004. A general strategy for hidden markov chain parameterisation in composite feature-spaces. Joint IAPR International Workshops, SSPR 2004 and SPR 2004. Lisbon, Portugal 18 - 20 Aug 2004 Springer. pp. 1069-1077 https://doi.org/10.1007/978-3-540-27868-9_118

A morphologically optimal strategy for classifier combination: Multiple expert fusion as a tomographic process

Windridge, D. and Kittler, J. 2003. A morphologically optimal strategy for classifier combination: Multiple expert fusion as a tomographic process. IEEE Transactions on Pattern Analysis and Machine Intelligence. 25 (3), pp. 343-353. https://doi.org/10.1109/TPAMI.2003.1182097