Predictors of treatment outcome in depression in later life: a systematic review and meta-analysis

Article

Tunvirachaisakul, C., Gould, R., Coulson, M., Ward, E., Reynolds, G., Gathercole, R., Grocott, H., Supasitthumrong, T., Tunvirachaisakul, A., Kimona, K. and Howard, R. 2018. Predictors of treatment outcome in depression in later life: a systematic review and meta-analysis. Journal of Affective Disorders. 227, pp. 164-182. https://doi.org/10.1016/j.jad.2017.10.008
TypeArticle
TitlePredictors of treatment outcome in depression in later life: a systematic review and meta-analysis
AuthorsTunvirachaisakul, C., Gould, R., Coulson, M., Ward, E., Reynolds, G., Gathercole, R., Grocott, H., Supasitthumrong, T., Tunvirachaisakul, A., Kimona, K. and Howard, R.
Abstract

Background: Predictor analyses of late-life depression can be used to identify variables associated with outcomes of treatments, and hence ways of tailoring specific treatments to patients. The aim of this review was to systematically identify, review and meta-analyse predictors of outcomes of any type of treatment for late-life depression.
Methods: Pubmed, Embase, CINAHL, Web of Science and PsycINFO were searched for studies published up to December 2016. Primary and secondary studies reported treatment predictors from randomised controlled trials of any treatment for patients with major depressive disorder aged over 60 were included. Treatment outcomes included response, remission and change in depression score.
Results: Sixty-seven studies met the inclusion criteria. Of 65 identified statistically significant predictors, only 7 were reported in at least 3 studies. Of these, 5 were included in meta-analyses, and only 3 were statistically significant. Most studies were rated as being of moderate to strong quality and satisfied key quality criteria for predictor analyses.
Limitations: The searches were limited to randomised controlled trials and most of the included studies were secondary analyses.
Conclusions: Baseline depression severity, co-morbid anxiety, executive dysfunction, current episode duration, early improvement, physical illnesses and age were reported as statistically significant predictors of treatment outcomes. Only the first three were significant in meta-analyses. Subgroup analyses showed differences in predictor effect between biological and psychosocial treatment. However, high heterogeneity and small study numbers suggest a cautious interpretation of results. These predictors were associated with various mechanisms including brain pathophysiology, perceived social support and proposed distinct types of depressive disorder. Further investigation of the clinical utility of these predictors is suggested.

KeywordsSystematic review; Meta-analysis; Predictor; Late-life depression; Major depressive disorder
PublisherElsevier
JournalJournal of Affective Disorders
ISSN0165-0327
Electronic1573-2517
Publication dates
Online10 Oct 2017
Print01 Feb 2018
Publication process dates
Deposited10 Oct 2017
Accepted01 Oct 2017
Output statusPublished
Accepted author manuscript
License
Copyright Statement

© 2017. This author's accepted manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

Digital Object Identifier (DOI)https://doi.org/10.1016/j.jad.2017.10.008
Web of Science identifierWOS:000424323600024
LanguageEnglish
Permalink -

https://repository.mdx.ac.uk/item/87348

Log in to edit

Download files

Accepted author manuscript
Final Accepted Manuscript 101017.docx
Final_Accepted_Manuscript_101017.pdf
License: CC BY-NC-ND 4.0

  • 63
    total views
  • 32
    total downloads
  • 2
    views this month
  • 2
    downloads this month

Export as

Related outputs

The effectiveness of individual and group canine assisted interventions in improving mental health in higher education students
Manville, K., Coulson, M. and Reynolds, G. 2024. The effectiveness of individual and group canine assisted interventions in improving mental health in higher education students. People and Animals: The International Journal of Research and Practice. 7 (1).
Age differences in priming as a function of processing at encoding
Ward, E. 2024. Age differences in priming as a function of processing at encoding. Consciousness and Cognition. 117. https://doi.org/10.1016/j.concog.2023.103626
An exploratory randomised controlled trial comparing the effectiveness of different duration of canine-assisted interventions in higher education students
Manville, K, Coulson, M and Reynolds, G. 2023. An exploratory randomised controlled trial comparing the effectiveness of different duration of canine-assisted interventions in higher education students. Human-Animal Interactions. 2023. https://doi.org/10.1079/hai.2023.0038
Null effects of temporal prediction on recognition memory but evidence for differential neural activity at encoding. A registered report
Jones, A., Silas, J., Anderson, W. and Ward, E. 2023. Null effects of temporal prediction on recognition memory but evidence for differential neural activity at encoding. A registered report. Cortex. 169, pp. 130-145. https://doi.org/10.1016/j.cortex.2023.09.006
Development and validation of the Music Cognitive Test: A music-based cognitive screening test
Mangiacotti, A., Cipriani, G., Ward, E., Franco, F. and Biasutti, M. 2023. Development and validation of the Music Cognitive Test: A music-based cognitive screening test. Psychology of Music. 51 (2), pp. 373-394. https://doi.org/10.1177/03057356221100851
A user-guided personalization methodology to facilitate new smart home occupancy
Ali, S.M.M., Augusto, J., Windridge, D. and Ward, E. 2023. A user-guided personalization methodology to facilitate new smart home occupancy. Universal Access in the Information Society. 22 (3), pp. 869-891. https://doi.org/10.1007/s10209-022-00883-x
Age and processing effects on perceptual and conceptual priming
Ward, E. 2023. Age and processing effects on perceptual and conceptual priming. Quarterly Journal of Experimental Psychology. 76 (1), pp. 1-14. https://doi.org/10.1177/17470218221090128
Effects of canine-assisted intervention on the mental health of higher education students: a systematic review
Manville, K., Coulson, M., Mulqueen, M., Neller, K., Searing, C., Welland, S. and Reynolds, G. 2022. Effects of canine-assisted intervention on the mental health of higher education students: a systematic review. Human-Animal Interaction Bulletin. 13 (1), pp. 111-145. https://doi.org/10.1079/hai.2022.0012
Canine-assisted intervention reduces anxiety and stress in higher education students: a randomized controlled trial
Manville, K., Coulson, M. and Reynolds, G. 2022. Canine-assisted intervention reduces anxiety and stress in higher education students: a randomized controlled trial. Society & Animals: Journal of Human-Animal Studies. 32 (2), pp. 156-177. https://doi.org/10.1163/15685306-bja10101
Temporal expectation improves recognition memory for spatially attended objects
Jones, A., Ward, E., Csiszer, E. and Szymczak, J. 2022. Temporal expectation improves recognition memory for spatially attended objects. Journal of Cognitive Neuroscience. 34 (9), pp. 1616-1629. https://doi.org/10.1162/jocn_a_01872
Paranoid and misidentification subtypes of psychosis in dementia
Pearce, D., Gould, R., Roughley, M., Reynolds, G., Ward, E., Bhome, R. and Reeves, S. 2022. Paranoid and misidentification subtypes of psychosis in dementia. Neuroscience & Biobehavioral Reviews. 134, pp. 1-11. https://doi.org/10.1016/j.neubiorev.2022.104529
The soundscape of neonatal intensive care: a mixed-methods study of the parents' experience
Chifa, M., Hadar, T., Politimou, N., Reynolds, G. and Franco, F. 2021. The soundscape of neonatal intensive care: a mixed-methods study of the parents' experience. Children. 8 (8). https://doi.org/10.3390/children8080644
Children's sleepiness facilitates the effect of vicarious learning on the development of fear
Reynolds, G. and Ewing, D. 2021. Children's sleepiness facilitates the effect of vicarious learning on the development of fear. Journal of Experimental Child Psychology. 208. https://doi.org/10.1016/j.jecp.2021.105129
Memory improvement in aging as a function of exposure to mood-matching music
Ward, E., Isac, A., Donnelly, M., Van Puyvelde, M. and Franco, F. 2021. Memory improvement in aging as a function of exposure to mood-matching music. Acta Psychologica. 212, pp. 1-6. https://doi.org/10.1016/j.actpsy.2020.103206
Aging predicts decline in explicit and implicit memory: a life-span study
Ward, E., Berry, C., Shanks, D., Moller, P. and Czsiser, E. 2020. Aging predicts decline in explicit and implicit memory: a life-span study. Psychological Science. 31 (9), pp. 1071-1083. https://doi.org/10.1177/0956797620927648
Rhythmic temporal structure at encoding enhances recognition memory
Jones, A. and Ward, E. 2019. Rhythmic temporal structure at encoding enhances recognition memory. Journal of Cognitive Neuroscience. 31 (10), pp. 1549-1562. https://doi.org/10.1162/jocn_a_01431
Multicomponent frailty assessment tools for older people with psychiatric disorders: a systematic review
Sutton, J., Gould, R., Coulson, M., Ward, E., Butler, A., Smith, M., Lavelle, G., Rosa, A., Langridge, M. and Howard, R. 2019. Multicomponent frailty assessment tools for older people with psychiatric disorders: a systematic review. Journal of the American Geriatrics Society. 67 (5), pp. 1085-1095. https://doi.org/10.1111/jgs.15710
Effects of vicarious disgust learning on the development of fear, disgust, and attentional biases in children
Reynolds, G. and Askew, C. 2019. Effects of vicarious disgust learning on the development of fear, disgust, and attentional biases in children. Emotion. 19 (7), p. 1268–1283. https://doi.org/10.1037/emo0000511
Implicit memory and cognitive aging
Ward, E. and Shanks, D. 2018. Implicit memory and cognitive aging. in: Braddick, O. (ed.) Oxford Research Encyclopedia of Psychology Oxford University Press (OUP).
The effects of exposure to images of others’ suffering and vulnerability on altruistic, trust-based, and reciprocated economic decision-making
Powell, P., Wills, O., Reynolds, G., Puustinen-Hopper, K. and Roberts, J. 2018. The effects of exposure to images of others’ suffering and vulnerability on altruistic, trust-based, and reciprocated economic decision-making. PLoS ONE. 13 (3), p. e0194569. https://doi.org/10.1371/journal.pone.0194569
The effect of stimulus duration on over-selectivity: evidence for the role of within-compound associations
Reynolds, G. and Reed, P. 2018. The effect of stimulus duration on over-selectivity: evidence for the role of within-compound associations. Journal of Experimental Psychology: Animal Learning and Cognition. 44 (3), pp. 293-308. https://doi.org/10.1037/xan0000175
TNF alpha inhibitors in Alzheimer's disease: A systematic review
Ekert, J., Gould, R., Reynolds, G. and Howard, R. 2018. TNF alpha inhibitors in Alzheimer's disease: A systematic review. International Journal of Geriatric Psychiatry. 33 (5), pp. 688-694. https://doi.org/10.1002/gps.4871
Reduced recognition and priming in older relative to young adults for incidental and intentional information
Ward, E. 2018. Reduced recognition and priming in older relative to young adults for incidental and intentional information. Consciousness and Cognition. 57, pp. 62-73. https://doi.org/10.1016/j.concog.2017.11.006
Reductions in children’s vicariously learnt avoidance and heart rate responses using positive modeling
Reynolds, G., Field, A. and Askew, C. 2018. Reductions in children’s vicariously learnt avoidance and heart rate responses using positive modeling. Journal of Clinical Child & Adolescent Psychology. 47 (4), pp. 555-568. https://doi.org/10.1080/15374416.2016.1138410
A comparison of positive vicarious learning and verbal information for reducing vicariously learned fear
Reynolds, G., Wasely, D., Dunne, G. and Askew, C. 2018. A comparison of positive vicarious learning and verbal information for reducing vicariously learned fear. Cognition and Emotion. 32 (6), pp. 1166-1177. https://doi.org/10.1080/02699931.2017.1389695
Does study duration have opposite effects on recognition and repetition priming?
Berry, C., Ward, E. and Shanks, D. 2017. Does study duration have opposite effects on recognition and repetition priming? Journal of Memory and Language. 97, pp. 154-174. https://doi.org/10.1016/j.jml.2017.07.004
Stimulus fear relevance and the speed, magnitude, and robustness of vicariously learned fear
Dunne, G., Reynolds, G. and Askew, C. 2017. Stimulus fear relevance and the speed, magnitude, and robustness of vicariously learned fear. Behaviour Research and Therapy. 95, pp. 1-18. https://doi.org/10.1016/j.brat.2017.05.002
A benefit of context reinstatement to recognition memory in aging: the role of familiarity processes
Ward, E., Maylor, E., Poirier, M., Korko, M. and Ruud, J. 2017. A benefit of context reinstatement to recognition memory in aging: the role of familiarity processes. Aging, Neuropsychology and Cognition. 24 (6), pp. 735-754. https://doi.org/10.1080/13825585.2016.1256371
Learning to fear a second-order stimulus following vicarious learning
Reynolds, G., Field, A. and Askew, C. 2017. Learning to fear a second-order stimulus following vicarious learning. Cognition and Emotion. 31 (3), pp. 572-579. https://doi.org/10.1080/02699931.2015.1116978
Editorial: The aging decision-maker: advances in understanding the impact of cognitive change on decision-making
Ward, E. and Dhami, M. 2016. Editorial: The aging decision-maker: advances in understanding the impact of cognitive change on decision-making. Frontiers in Psychology. 7. https://doi.org/10.3389/fpsyg.2016.01622
Psychometric properties of multicomponent tools designed to assess frailty in older adults: A systematic review
Sutton, J., Gould, R., Daley, S., Coulson, M., Ward, E., Butler, A., Nunn, S. and Howard, R. 2016. Psychometric properties of multicomponent tools designed to assess frailty in older adults: A systematic review. BMC Geriatrics. 16 (1), pp. 1-20. https://doi.org/10.1186/s12877-016-0225-2
Inhibition of vicariously learned fear in children using positive modeling and prior exposure
Askew, C., Reynolds, G., Fielding-Smith, S. and Field, A. 2016. Inhibition of vicariously learned fear in children using positive modeling and prior exposure. Journal of Abnormal Psychology. 125 (2), pp. 279-291. https://doi.org/10.1037/abn0000131
Tests of pattern separation and pattern completion in humans - a systematic review
Liu, K., Gould, R., Coulson, M., Ward, E. and Howard, R. 2016. Tests of pattern separation and pattern completion in humans - a systematic review. Hippocampus. 26 (6), pp. 705-717. https://doi.org/10.1002/hipo.22561
Stimulus fear-relevance and the vicarious learning pathway to childhood fears
Askew, C., Dunne, G., Ozdil, Z., Reynolds, G. and Field, A. 2013. Stimulus fear-relevance and the vicarious learning pathway to childhood fears. Emotion. 13 (5), pp. 915-925. https://doi.org/10.1037/a0032714
The strength and generality of stimulus over-selectivity in simultaneous discrimination procedures
Reynolds, G. and Reed, P. 2011. The strength and generality of stimulus over-selectivity in simultaneous discrimination procedures. Learning and Motivation. 42 (2), pp. 113-122. https://doi.org/10.1016/j.lmot.2010.12.001
Effects of schedule of reinforcement on over-selectivity
Reynolds, G. and Reed, P. 2011. Effects of schedule of reinforcement on over-selectivity. Research in Developmental Disabilities. 32 (6), pp. 2489-2501. https://doi.org/10.1016/j.ridd.2011.07.011
Preventing the development of observationally learnt fears in children by devaluing the model's negative response
Reynolds, G., Field, A. and Askew, C. 2015. Preventing the development of observationally learnt fears in children by devaluing the model's negative response. Journal of Abnormal Child Psychology. 43 (7), pp. 1355-1367. https://doi.org/10.1007/s10802-015-0004-0
Greater priming for previously distracting information in young than older adults when suppression is ruled out
Ward, E., De Mornay Davies, P. and Politimou, N. 2015. Greater priming for previously distracting information in young than older adults when suppression is ruled out. Aging, Neuropsychology and Cognition. 22 (6), pp. 712-730. https://doi.org/10.1080/13825585.2015.1035224
Effect of vicarious fear learning on children's heart rate responses and attentional bias for novel animals
Reynolds, G., Field, A. and Askew, C. 2014. Effect of vicarious fear learning on children's heart rate responses and attentional bias for novel animals. Emotion. 14 (5), pp. 995-1006. https://doi.org/10.1037/a0037225
The effect of disgust and fear modeling on children’s disgust and fear for animals
Askew, C., Çakır, K., Põldsam, L. and Reynolds, G. 2014. The effect of disgust and fear modeling on children’s disgust and fear for animals. Journal of Abnormal Psychology. 123 (3), pp. 566-577. https://doi.org/10.1037/a0037228
Effect of a surprising downward shift in reinforcer value on stimulus over-selectivity in a simultaneous discrimination procedure
Reynolds, G. and Reed, P. 2013. Effect of a surprising downward shift in reinforcer value on stimulus over-selectivity in a simultaneous discrimination procedure. Learning and Motivation. 44 (1), pp. 31-45. https://doi.org/10.1016/j.lmot.2012.05.007
An effect of age on implicit memory that is not due to explicit contamination: implications for single and multiple-systems theories
Ward, E., Berry, C. and Shanks, D. 2013. An effect of age on implicit memory that is not due to explicit contamination: implications for single and multiple-systems theories. Psychology and Aging. 28 (2), pp. 429-442. https://doi.org/10.1037/a0031888
Age effects on explicit and implicit memory
Ward, E., Berry, C. and Shanks, D. 2013. Age effects on explicit and implicit memory. Frontiers in Psychology. 4. https://doi.org/10.3389/fpsyg.2013.00639
Lack of evidence for inhibitory processes in over-selectivity
Reynolds, G., Watts, J. and Reed, P. 2012. Lack of evidence for inhibitory processes in over-selectivity. Behavioural Processes. 89 (1), pp. 14-22. https://doi.org/10.1016/j.beproc.2011.09.008
Revaluation manipulations produce emergence of underselected stimuli following simultaneous discrimination in humans
Reed, P., Reynolds, G. and Fermandel, L. 2012. Revaluation manipulations produce emergence of underselected stimuli following simultaneous discrimination in humans. Quarterly Journal of Experimental Psychology. 65 (7), pp. 1345-1360. https://doi.org/10.1080/17470218.2012.656663