Suppressive effects of exercise-conditioned serum on cancer cells: A narrative review of the influence of exercise mode, volume, and intensity
Article
Bettariga, F., Taaffe, D., Galvão, D., Bishop, C., Kim, J. and Newton, R. 2024. Suppressive effects of exercise-conditioned serum on cancer cells: A narrative review of the influence of exercise mode, volume, and intensity. Journal of Sport and Health Science. 13 (4), pp. 484-498. https://doi.org/10.1016/j.jshs.2023.12.001
Type | Article |
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Title | Suppressive effects of exercise-conditioned serum on cancer cells: A narrative review of the influence of exercise mode, volume, and intensity |
Authors | Bettariga, F., Taaffe, D., Galvão, D., Bishop, C., Kim, J. and Newton, R. |
Abstract | Cancer is a major cause of morbidity and mortality worldwide, and the incidence is increasing, highlighting the need for effective strategies to treat this disease. Exercise has emerged as fundamental therapeutic medicine in the management of cancer, associated with a lower risk of recurrence and increased survival. Several avenues of research demonstrate reduction in growth, proliferation, and increased apoptosis of cancer cells, including breast, prostate, colorectal, and lung cancer, when cultured by serum collected after exercise in vitro (i.e., the cultivation of cancer cell lines in an experimental setting, which simplifies the biological system and provides mechanistic insight into cell responses). The underlying mechanisms of exercise-induced cancer suppressive effects may be attributed to the alteration in circulating factors, such as skeletal muscle-induced cytokines (i.e., myokines) and hormones. However, exercise-induced tumor suppressive effects and detailed information about training interventions are not well investigated, constraining more precise application of exercise medicine within clinical oncology. To date, it remains unclear what role different training modes (i.e., resistance and aerobic training) as well as volume and intensity have on exercise-conditioned serum and its effects on cancer cells. Nevertheless, the available evidence is that a single bout of aerobic training at moderate to vigorous intensity has cancer suppressive effects, while for chronic training interventions, exercise volume appears to be an influential candidate driving cancer inhibitory effects regardless of training mode. Insights for future research investigating training modes, volume and intensity are provided to further our understanding of the effects of exercise-conditioned serum on cancer cells. [Abstract copyright: Copyright © 2023. Production and hosting by Elsevier B.V.] |
Keywords | Myokines; Resistance training; High intensity interval training; Moderate intensity continuous training; Cancer cells |
Sustainable Development Goals | 3 Good health and well-being |
Middlesex University Theme | Health & Wellbeing |
Publisher | Elsevier |
Journal | Journal of Sport and Health Science |
ISSN | 2095-2546 |
Electronic | 2213-2961 |
Publication dates | |
Online | 10 Dec 2023 |
Jul 2024 | |
Publication process dates | |
Submitted | 26 Jun 2023 |
Accepted | 13 Nov 2023 |
Deposited | 25 Jul 2024 |
Output status | Published |
Publisher's version | License File Access Level Open |
Copyright Statement | © 2024 Published by Elsevier B.V. on behalf of Shanghai University of Sport. This is an open access article under the CC BY-NC-ND license. |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.jshs.2023.12.001 |
PubMed ID | 38081360 |
Language | English |
https://repository.mdx.ac.uk/item/1716z2
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